COMSA was a Spanish railway infrastructure and construction company.
COMSA or Comsa may also refer to:
- Canadian Osteopathic Medical Student Association
- Dimitrie Comșa (1846-1931), Transylvanian Romanian agronomer and activist
- Grigorie Comșa (1889–1935), a bishop in the Romanian Orthodox Church
- The "College of Maritime and Shipping Administration" at the Palompon Institute of Technology in the Philippines