COPS7A

COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.

COPS7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4WSN
Identifiers
Aliases	COPS7A, CSN7A, SGN7a, CSN7, COP9 signalosome subunit 7A
External IDs	OMIM: 616009; MGI: 1349400; HomoloGene: 22685; GeneCards: COPS7A; OMA:COPS7A - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,724,014 bp End 6,731,875 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 F2|6 59.17 cM Start 124,935,376 bp End 124,942,501 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex stromal cell of endometrium right frontal lobe cingulate gyrus anterior cingulate cortex Brodmann area 9 apex of heart right adrenal gland right adrenal cortex gastrocnemius muscle Top expressed in spermatocyte spermatid muscle of thigh tail of embryo genital tubercle yolk sac dentate gyrus of hippocampal formation granule cell superior frontal gyrus lip blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component COP9 signalosome nucleus nucleoplasm cytoplasm cytosol Biological process transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA damage recognition protein deneddylation post-translational protein modification viral process COP9 signalosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50813 26894 Ensembl ENSG00000111652 ENSMUSG00000030127 UniProt Q9UBW8 Q9CZ04 RefSeq (mRNA) NM_001164093 NM_001164094 NM_001164095 NM_016319 NM_001164089 NM_012003 NM_001355541 NM_001355542 NM_001379119 NM_001379120 NM_001379122 NM_001379123 NM_001379124 NM_001379125 RefSeq (protein) NP_001157565 NP_001157566 NP_001157567 NP_057403 NP_001157561 NP_036133 NP_001342470 NP_001342471 NP_001366048 NP_001366049 NP_001366051 NP_001366052 NP_001366053 NP_001366054 Location (UCSC) Chr 12: 6.72 – 6.73 Mb Chr 6: 124.94 – 124.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human COPS7A genome location and COPS7A gene details page in the UCSC Genome Browser.

Further reading

• Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295. S2CID 37458780.
• Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.
• Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. Bibcode:1998CBio....8..919W. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402. S2CID 13873982.
• Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
• Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci...292.1382L. doi:10.1126/science.1059780. PMID 11337588. S2CID 14224920.
• Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626. S2CID 39308598.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell. 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
• Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
• Groisman R, Polanowska J, Kuraoka I, Sawada JI, Saijo M, Drapkin R, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143. S2CID 11639677.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.