COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.[5][6][7]

COPS8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOPS8, COP9, CSN8, SGN8, COP9 signalosome subunit 8
External IDsOMIM: 616011; MGI: 1915363; HomoloGene: 4882; GeneCards: COPS8; OMA:COPS8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198189
NM_006710

NM_133805

RefSeq (protein)

NP_006701
NP_937832

NP_598566

Location (UCSC)Chr 2: 237.09 – 237.1 MbChr 1: 90.53 – 90.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198612Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034432Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chamovitz DA, Deng XW (Sep 1995). "The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms". Cell. 82 (3): 353–4. doi:10.1016/0092-8674(95)90423-9. PMID 7634324.
  6. ^ Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, et al. (May 2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143. S2CID 11639677.
  7. ^ a b "Entrez Gene: COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)".
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Further reading

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