COU is an acronym with several meanings:
- (Cone of Uncertainty)
Area used to project where a hurricane may go Also a band in New Orleans
- Columbia Regional Airport
- Comité Olímpico Uruguayo, the Uruguayan Olympic Committee
- Context of Use, with respect to biomarker-based evidence assessed at the US FDA
- Council of Ontario Universities
- Unidad de Valor Real, a reference currency of Columbia, by ISO 4217 currency code
- Curso de Orientación Universitaria, a sidancro former Spanish Pre-University academic course.