CP-1414S

CP-1414S
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-phenyl-4-amino-8-nitro-3H-1,5-benzodiazepin-2-one;
CAS Number	36975-99-2 ;
PubChem CID	37594;
ChemSpider	34483 ;
UNII	PX48L7VRQ2;
CompTox Dashboard (EPA)	DTXSID50958148 ;
Chemical and physical data
Formula	C15H12N4O3
Molar mass	296.286 g·mol−1
	InChI InChI=1S/C15H12N4O3/c16-14-9-15(20)18(10-4-2-1-3-5-10)13-8-11(19(21)22)6-7-12(13)17-14/h1-8H,9H2,(H2,16,17) ; Key:MBSVPZTUXNRICW-UHFFFAOYSA-N ;
	(verify)

CP-1414S is an experimental drug first made by a team in Germany.^[1] It is a benzodiazepine derivative. CP-1414S is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.

CP-1414S has primarily anxiolytic and anticonvulsant effects.^[2] Its potency is roughly equal to that of clobazam, but with more pronounced sedation.^[3]

References

^ US Patent 3766169 PROCESS FOR THE PREPARATION OF 3-AMINOMETHYLIDENE-1,5-BENZODIAZEPINE-2,4-(3H,5H)-DIONES
^ Carli M, Ballabio M, Caccia S, Garattini S, Samanin R (1981). "Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam". Arzneimittel-Forschung. 31 (10): 1721–3. PMID 6119091.
^ Mennini T, Garattini S (November 1982). "Benzodiazepine receptors': correlation with pharmacological responses in living animals". Life Sciences. 31 (19): 2025–35. doi:10.1016/0024-3205(82)90094-7. PMID 6129557.

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[1] US Patent 3766169 PROCESS FOR THE PREPARATION OF 3-AMINOMETHYLIDENE-1,5-BENZODIAZEPINE-2,4-(3H,5H)-DIONES

[pmid6119091-2] Carli M, Ballabio M, Caccia S, Garattini S, Samanin R (1981). "Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam". Arzneimittel-Forschung. 31 (10): 1721–3. PMID 6119091.

[pmid6129557-3] Mennini T, Garattini S (November 1982). "Benzodiazepine receptors': correlation with pharmacological responses in living animals". Life Sciences. 31 (19): 2025–35. doi:10.1016/0024-3205(82)90094-7. PMID 6129557.

[1]

[2]

[3]

Clinical data

ATC code	none
Identifiers
IUPAC name 1-phenyl-4-amino-8-nitro-3H-1,5-benzodiazepin-2-one
CAS Number	36975-99-2^Y
PubChem CID	37594
ChemSpider	34483^Y
UNII	PX48L7VRQ2
CompTox Dashboard (EPA)	DTXSID50958148
Chemical and physical data
Formula	C₁₅H₁₂N₄O₃
Molar mass	296.286 g·mol⁻¹
InChI InChI=1S/C15H12N4O3/c16-14-9-15(20)18(10-4-2-1-3-5-10)13-8-11(19(21)22)6-7-12(13)17-14/h1-8H,9H2,(H2,16,17)^Y Key:MBSVPZTUXNRICW-UHFFFAOYSA-N^Y
(verify)

CP-1414S

See also

References