CPEB1

Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1 gene.

CPEB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M13, 2MKH, 2MKK, 2N1O
Identifiers
Aliases	CPEB1, CEBP, CPE-BP1, CPEB, CPEB-1, hCPEB-1, h-CPEB, cytoplasmic polyadenylation element binding protein 1
External IDs	OMIM: 607342; MGI: 108442; HomoloGene: 7278; GeneCards: CPEB1; OMA:CPEB1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.2 Start 82,543,201 bp End 82,648,861 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D3 Start 80,996,774 bp End 81,105,213 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle C1 segment Pituitary Gland anterior pituitary Brodmann area 9 right testis corpus callosum superior frontal gyrus left testis substantia nigra Top expressed in primary oocyte superior frontal gyrus muscle of thigh dentate gyrus of hippocampal formation granule cell primary visual cortex secondary oocyte lumbar spinal ganglion anterior horn of spinal cord triceps brachii muscle zygote More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding mRNA 3'-UTR AU-rich region binding translation factor activity, RNA binding RNA binding nucleic acid binding ribosome binding translation repressor activity, mRNA regulatory element binding mRNA 3'-UTR binding translation regulator activity protein binding Cellular component synapse cell projection cell junction neuron projection messenger ribonucleoprotein complex postsynaptic density postsynaptic membrane membrane P-body dendrite plasma membrane cytoplasm nucleus nucleoplasm cytosol Biological process cellular response to insulin stimulus regulation of translation negative regulation of cytoplasmic translation mRNA processing cellular response to amino acid stimulus cellular response to hypoxia protein biosynthesis positive regulation of mRNA polyadenylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64506 12877 Ensembl ENSG00000277445 ENSG00000214575 ENSMUSG00000025586 UniProt Q9BZB8 P70166 RefSeq (mRNA) NM_030594 NM_001079533 NM_001079534 NM_001079535 NM_001288819 NM_001288820 NM_001252525 NM_001252526 NM_007755 NM_001357107 RefSeq (protein) NP_001073001 NP_001073002 NP_001073003 NP_001275748 NP_001275749 NP_085097 NP_001352169 NP_001352170 NP_001352171 NP_001352172 NP_001352173 NP_001352174 NP_001352175 NP_001352176 NP_001352177 NP_001352178 NP_001352179 NP_001239454 NP_001239455 NP_031781 NP_001344036 Location (UCSC) Chr 15: 82.54 – 82.65 Mb Chr 7: 81 – 81.11 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Mendez R, Richter JD (2001). "Translational control by CPEB: a means to the end". Nat. Rev. Mol. Cell Biol. 2 (7): 521–9. doi:10.1038/35080081. PMID 11433366. S2CID 815958.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilczynska A, Aigueperse C, Kress M, et al. (2005). "The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules". J. Cell Sci. 118 (Pt 5): 981–92. doi:10.1242/jcs.01692. PMID 15731006.
• Sasayama T, Marumoto T, Kunitoku N, et al. (2005). "Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1". Genes Cells. 10 (7): 627–38. doi:10.1111/j.1365-2443.2005.00870.x. hdl:20.500.14094/D2002840. PMID 15966895. S2CID 24879593.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• Human CPEB1 genome location and CPEB1 gene details page in the UCSC Genome Browser.