CRACR2A

Calcium release activated channel regulator 2A is a protein that in humans is encoded by the CRACR2A gene.

CRACR2A
Identifiers
Aliases	CRACR2A, EFCAB4B, calcium release activated channel regulator 2A, RAB46
External IDs	OMIM: 614178; MGI: 2685919; HomoloGene: 41883; GeneCards: CRACR2A; OMA:CRACR2A - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.32 Start 3,606,633 bp End 3,764,819 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F3 Start 127,538,301 bp End 127,651,211 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of ileum mucosa of sigmoid colon nasal epithelium rectum olfactory zone of nasal mucosa trachea minor salivary glands bone marrow cells bronchial epithelial cell Top expressed in granulocyte colon lung jejunum ileum morula thymus duodenum bone marrow stomach More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding calcium ion binding protein binding Cellular component cytoplasm membrane extracellular region specific granule lumen Biological process ion transport adaptive immune response activation of store-operated calcium channel activity calcium ion transport store-operated calcium entry positive regulation of calcium ion transport immune system process neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84766 381812 Ensembl ENSG00000130038 ENSMUSG00000061414 UniProt Q9BSW2 Q3UP38 RefSeq (mRNA) NM_001144958 NM_001144959 NM_032680 NM_001033464 NM_001368877 RefSeq (protein) NP_001138430 NP_116069 NP_001028636 NP_001355806 Location (UCSC) Chr 12: 3.61 – 3.76 Mb Chr 6: 127.54 – 127.65 Mb PubMed search
Wikidata
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Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y (2010). "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells". Nat. Cell Biol. 12 (5): 436–46. doi:10.1038/ncb2045. PMC 2875865. PMID 20418871.
• Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, Cui J, Taylor KD, Wilson L, Cummings OW, Chen YD, Rotter JI (2010). "Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease". Gastroenterology. 139 (5): 1567–76, 1576.e1–6. doi:10.1053/j.gastro.2010.07.057. PMC 2967576. PMID 20708005.