CTNNBIP1

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.

CTNNBIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M1E, 1T08
Identifiers
Aliases	CTNNBIP1, ICAT, catenin beta interacting protein 1
External IDs	OMIM: 607758; MGI: 1915756; HomoloGene: 10641; GeneCards: CTNNBIP1; OMA:CTNNBIP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.22 Start 9,848,276 bp End 9,910,336 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 E2 Start 149,602,693 bp End 149,650,894 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen skin of thigh skin of arm nipple apex of heart human penis skin of hip olfactory zone of nasal mucosa paraflocculus of cerebellum Top expressed in saccule habenula otic placode lip esophagus otic vesicle skin of external ear ventricular zone medial ganglionic eminence neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function beta-catenin binding protein binding armadillo repeat domain binding Cellular component cytoplasm cytosol nucleoplasm nucleus beta-catenin destruction complex Biological process negative regulation of smooth muscle cell proliferation negative regulation of protein-containing complex assembly negative regulation of DNA binding negative regulation of Wnt signaling pathway regulation of vascular permeability involved in acute inflammatory response negative regulation of transcription by RNA polymerase II Wnt signaling pathway negative regulation of protein binding negative regulation of DNA-binding transcription factor activity branching involved in ureteric bud morphogenesis positive regulation of osteoblast differentiation positive regulation of monocyte differentiation negative regulation of transcription initiation from RNA polymerase II promoter negative regulation of mesenchymal cell proliferation anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56998 67087 Ensembl ENSG00000178585 ENSMUSG00000028988 UniProt Q9NSA3 Q9JJN6 RefSeq (mRNA) NM_020248 NM_001012329 NM_001141930 NM_023465 RefSeq (protein) NP_001012329 NP_064633 NP_001135402 NP_075954 Location (UCSC) Chr 1: 9.85 – 9.91 Mb Chr 4: 149.6 – 149.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. The encoded protein is a negative regulator of the Wnt signaling pathway.

Further reading

• Yochum GS, Cleland R, Goodman RH (2008). "A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression". Mol. Cell. Biol. 28 (24): 7368–79. doi:10.1128/MCB.00744-08. PMC 2593444. PMID 18852287.
• Sharma M, Henderson BR (2007). "IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli". J. Biol. Chem. 282 (11): 8545–56. doi:10.1074/jbc.M610272200. PMID 17255093.
• Takeda K, Kinoshita I, Shimizu Y, et al. (2008). "Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors". BMC Cancer. 8: 328. doi:10.1186/1471-2407-8-328. PMC 2585585. PMID 18992165.
• Wang W, Zhang X, Deng K, et al. (2009). "ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657". Cell Biochem. Funct. 27 (6): 329–37. doi:10.1002/cbf.1576. PMID 19569129. S2CID 36742591.
• Wang WJ, Tang W, Qiu ZY (2009). "Comparative proteomics analysis on differentiation of human promyelocytic leukemia HL-60 cells into granulocyte and monocyte lineages". AI Zheng. 28 (2): 117–21. PMID 19550115.
• Reichel O, Mayr D, Durst F, Berghaus A (2008). "E-cadherin but not beta-catenin expression is decreased in laryngeal biopsies from patients with laryngopharyngeal reflux". Eur Arch Otorhinolaryngol. 265 (8): 937–42. doi:10.1007/s00405-007-0568-6. PMID 18183411. S2CID 9080577.
• Bazas VM, Lukyanova NY, Demash DV, et al. (2008). "Relation between cell-to-cell adhesion and angiogenesis and clinico-morphological prognostic factors in patients with gastric cancer". Exp. Oncol. 30 (3): 235–9. PMID 18806748.
• Kohler EM, Chandra SH, Behrens J, Schneikert J (2009). "Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours". Hum. Mol. Genet. 18 (2): 213–26. doi:10.1093/hmg/ddn338. PMID 18854359.
• Seo E, Jho EH (2007). "Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin". Biochem. Biophys. Res. Commun. 357 (1): 81–6. doi:10.1016/j.bbrc.2007.03.117. PMID 17418091.
• Ladeiro Y, Couchy G, Balabaud C, et al. (2008). "MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations" (PDF). Hepatology. 47 (6): 1955–63. doi:10.1002/hep.22256. PMID 18433021. S2CID 15190293.
• Zhang H, Xue Y (2008). "Wnt pathway is involved in advanced gastric carcinoma". Hepatogastroenterology. 55 (84): 1126–30. PMID 18705344.
• Wang HX, Tekpetey FR, Kidder GM (2009). "Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells". Mol. Hum. Reprod. 15 (1): 11–7. doi:10.1093/molehr/gan070. PMID 19038973.
• Matono H, Oda Y, Nakamori M, et al. (2008). "Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors". Hum. Pathol. 39 (12): 1802–8. doi:10.1016/j.humpath.2008.05.005. PMID 18715618.
• Wang L, O'Leary H, Fortney J, Gibson LF (2007). "Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells". Blood. 110 (9): 3334–44. doi:10.1182/blood-2007-01-068122. PMC 2200915. PMID 17638851.
• von Koch CS, Gulati M, Aldape K, Berger MS (2002). "Familial medulloblastoma: case report of one family and review of the literature". Neurosurgery. 51 (1): 227–33, discussion 233. doi:10.1097/00006123-200207000-00035. PMID 12182422. S2CID 21293611.
• Wang L, Li H, Zhang Y, et al. (2009). "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells". Int. J. Cancer. 124 (7): 1526–34. doi:10.1002/ijc.24072. PMC 2667231. PMID 19089909.
• Chen Y, Bodles AM (2007). "Amyloid precursor protein modulates beta-catenin degradation". Journal of Neuroinflammation. 4: 29. doi:10.1186/1742-2094-4-29. PMC 2231348. PMID 18070361.
• Kastritis E, Murray S, Kyriakou F, et al. (2009). "Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication". Int. J. Cancer. 124 (1): 103–8. doi:10.1002/ijc.23917. PMID 18844223.
• Turbiner J, Moreno-Bueno G, Dahiya S, et al. (2008). "Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen". Mod. Pathol. 21 (8): 925–36. doi:10.1038/modpathol.2008.49. PMID 18500270.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• CTNNBIP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CTNNBIP1 genome location and CTNNBIP1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.