CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene .[ 5] [ 6] [ 7]
CXXC1 Identifiers Aliases CXXC1 External IDs OMIM : 609150 ; MGI : 1921572 ; HomoloGene : 32221 ; GeneCards : CXXC1 ; OMA :CXXC1 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in right hemisphere of cerebellum body of pancreas right uterine tube pancreatic ductal cell granulocyte right lobe of thyroid gland skin of leg sural nerve skin of abdomen left lobe of thyroid gland
Top expressed in Ileal epithelium tail of embryo genital tubercle neural layer of retina choroid plexus of fourth ventricle lactiferous gland entorhinal cortex perirhinal cortex secondary oocyte otic vesicle
More reference expression data
BioGPS
Wikidata
Proteins that contain a CXXC motif within their DNA-binding domain , such as CXXC1, recognize CpG sequences and regulate gene expression .[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000154832 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024560 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun . 271 (2): 305–310. doi :10.1006/bbrc.2000.2614 . PMID 10799292 . ^ a b Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1" . Mol Cell Biol . 20 (6): 2108–2121. doi :10.1128/MCB.20.6.2108-2121.2000 . PMC 110827 PMID 10688657 . ^ "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)" .
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–435. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–292. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Lee JH, Voo KS, Skalnik DG (2002). "Identification and characterization of the DNA binding domain of CpG-binding protein" . J. Biol. Chem . 276 (48): 44669–44676. doi :10.1074/jbc.M107179200 PMID 11572867 . Carlone DL, Skalnik DG (2001). "CpG binding protein is crucial for early embryonic development" . Mol. Cell. Biol . 21 (22): 7601–7606. doi :10.1128/MCB.21.22.7601-7606.2001 . PMC 99931 PMID 11604496 . Lee JH, Skalnik DG (2003). "CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals" . J. Biol. Chem . 277 (44): 42259–42267. doi :10.1074/jbc.M205054200 PMID 12200428 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–1625. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . S2CID 39457788 . Lee JH, Skalnik DG (2006). "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex" . J. Biol. Chem . 280 (50): 41725–41731. doi :10.1074/jbc.M508312200 PMID 16253997 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–814. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Young SR, Skalnik DG (2007). "CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line". DNA Cell Biol . 26 (2): 80–90. doi :10.1089/dna.2006.0535 . PMID 17328666 .
