CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.[5][6][7]

CXXC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCXXC1, 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP, CXXC finger protein 1
External IDsOMIM: 609150; MGI: 1921572; HomoloGene: 32221; GeneCards: CXXC1; OMA:CXXC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001101654
NM_014593

NM_028868
NM_001378844

RefSeq (protein)

NP_001095124
NP_055408

NP_083144
NP_001365773

Location (UCSC)Chr 18: 50.28 – 50.29 MbChr 18: 74.35 – 74.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154832Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024560Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun. 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292.
  6. ^ a b Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1". Mol Cell Biol. 20 (6): 2108–2121. doi:10.1128/MCB.20.6.2108-2121.2000. PMC 110827. PMID 10688657.
  7. ^ "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)".
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Further reading

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