CYB5R2

Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene.

CYB5R2
Identifiers
Aliases	CYB5R2, B5R.2, cytochrome b5 reductase 2
External IDs	OMIM: 608342; MGI: 2444415; HomoloGene: 6182; GeneCards: CYB5R2; OMA:CYB5R2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 7,665,100 bp End 7,677,222 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E3 Start 107,347,662 bp End 107,357,239 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis tibial nerve sperm sural nerve skin of abdomen skin of leg olfactory zone of nasal mucosa minor salivary glands C1 segment Top expressed in zygote spermatid lens sciatic nerve secondary oocyte morula embryo muscle of thigh spermatocyte seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein binding cytochrome-b5 reductase activity, acting on NAD(P)H FAD binding Cellular component nucleus membrane endoplasmic reticulum membrane mitochondrion Biological process steroid metabolic process sterol biosynthetic process steroid biosynthetic process lipid metabolism bicarbonate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51700 320635 Ensembl ENSG00000166394 ENSMUSG00000048065 UniProt Q6BCY4 Q3KNK3 RefSeq (mRNA) NM_001001336 NM_001302826 NM_001302827 NM_016229 NM_001205227 NM_177216 RefSeq (protein) NP_001289755 NP_001289756 NP_057313 NP_001192156 NP_796190 Location (UCSC) Chr 11: 7.67 – 7.68 Mb Chr 7: 107.35 – 107.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CYB5R2 genome location and CYB5R2 gene details page in the UCSC Genome Browser.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Heard-Costa NL, Zillikens MC, Monda KL, et al. (2009). Dermitzakis ET (ed.). "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium". PLOS Genet. 5 (6): e1000539. doi:10.1371/journal.pgen.1000539. PMC 2695005. PMID 19557197.
• Zhu H, Qiu H, Yoon HW, et al. (1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Baker MA, Krutskikh A, Curry BJ, et al. (2005). "Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa". Biol. Reprod. 73 (2): 334–42. doi:10.1095/biolreprod.104.037960. PMID 15858218.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.