The Cyp11a2 is a fish gene encoding a CYP450 monooxygenase,[1] which was originally identified in Zebrafish (Danio rerio),[2] is the isozyme and paralogous of fish CYP11A1, catalyzes conversion of cholesterol to pregnenolone.[3]
| cytochrome P450, family 11, subfamily a, polypeptide 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | CYP11A2 | ||||||
| Entrez | 563363 | ||||||
| HomoloGene | 37347 | ||||||
| RefSeq (mRNA) | XM_686725.7 | ||||||
| RefSeq (Prot) | XP_691817.1 | ||||||
| UniProt | F1R1K0 | ||||||
| Other data | |||||||
| EC number | 1.14.15.6 | ||||||
| Chromosome | 25: 22.3 - 22.31 Mb | ||||||
| |||||||
References
edit- ^ Uno T, Ishizuka M, Itakura T (July 2012). "Cytochrome P450 (CYP) in fish". Environmental Toxicology and Pharmacology. 34 (1): 1–13. Bibcode:2012EnvTP..34....1U. doi:10.1016/j.etap.2012.02.004. PMID 22418068.
- ^ Parajes S, Griffin A, Taylor AE, Rose IT, Miguel-Escalada I, Hadzhiev Y, et al. (August 2013). "Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme cyp11a2". Endocrinology. 154 (8): 2702–11. doi:10.1210/en.2013-1145. PMID 23671259.
- ^ Li N, Oakes JA, Storbeck KH, Cunliffe VT, Krone NP (February 2020). "The P450 side-chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish". The Journal of Endocrinology. 244 (2): 309–321. doi:10.1530/JOE-19-0384. PMID 31693487.
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