CYP6M2 is a gene location in Anopheles gambiae chromosome 3R, involved in the insecticide resistant.[1] The enzyme encoded by this gene is capable of directly metabolizing pyrethroids,[2] belongs to the cytochrome P450 family CYP6[3]
| Cytochrome P450 6m2 | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | Cyp6m2 |
| Entrez | 5668319 |
| Other data | |
| EC number | 1.14.-.- |
References
edit- ^ Djouaka, RF; Bakare, AA; Coulibaly, ON; Akogbeto, MC; Ranson, H; Hemingway, J; Strode, C (13 November 2008). "Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria". BMC Genomics. 9: 538. doi:10.1186/1471-2164-9-538. PMC 2588609. PMID 19014539.
- ^ Ismail HM, O'Neill PM, Hong DW, Finn RD, Henderson CJ, Wright AT, et al. (December 2013). "Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions". Proceedings of the National Academy of Sciences of the United States of America. 110 (49): 19766–71. Bibcode:2013PNAS..11019766I. doi:10.1073/pnas.1320185110. PMC 3856776. PMID 24248381.
- ^ Wagah, MG; Korlević, P; Clarkson, C; Miles, A; Anopheles gambiae 1000 Genomes, Consortium.; Lawniczak, MKN; Makunin, A (25 May 2021). "Genetic variation at the Cyp6m2 putative insecticide resistance locus in Anopheles gambiae and Anopheles coluzzii". Malaria Journal. 20 (1): 234. doi:10.1186/s12936-021-03757-4. PMC 8146665. PMID 34034756.
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External links
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