CYREN (protein)

Cell cycle regulator of non-homologous end joining is a protein that in humans is encoded by the CYREN gene.

CYREN
Identifiers
Aliases	CYREN, MRI, chromosome 7 open reading frame 49, MRI-2, C7orf49, cell cycle regulator of NHEJ
External IDs	OMIM: 616980; MGI: 1925662; HomoloGene: 49745; GeneCards: CYREN; OMA:CYREN - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q33 Start 135,092,363 bp End 135,170,795 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B1 Start 34,848,706 bp End 34,854,995 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle right lung monocyte granulocyte right lobe of liver upper lobe of left lung C1 segment gastric mucosa Descending thoracic aorta tibial nerve Top expressed in granulocyte bone marrow yolk sac muscle of thigh embryo proximal tubule quadriceps femoris muscle muscle tissue ventricular zone liver More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus Biological process double-strand break repair via nonhomologous end joining DNA repair cellular response to DNA damage stimulus negative regulation of double-strand break repair via nonhomologous end joining Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 78996 78412 Ensembl ENSG00000122783 ENSMUSG00000046806 UniProt Q9BWK5 Q8BHZ5 RefSeq (mRNA) NM_024033 NM_001243749 NM_001243751 NM_001243752 NM_001243753 NM_001243754 NM_001243755 NM_001305629 NM_001305630 NM_001363329 NM_001363330 NM_001135611 NM_199145 NM_001347101 RefSeq (protein) NP_001230678 NP_001230680 NP_001230681 NP_001230682 NP_001230683 NP_001230684 NP_001292558 NP_001292559 NP_076938 NP_001350258 NP_001350259 NP_001129083 NP_001334030 NP_954596 Location (UCSC) Chr 7: 135.09 – 135.17 Mb Chr 6: 34.85 – 34.85 Mb PubMed search
Wikidata
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It prevents classical non-homologous end joining, a method of repair of double-stranded DNA breaks. This protein is therefore important in regulating DNA repair.

When alternatively spliced, is predicted to produce three different micropeptides.

• MRI-1 was previously found to be a modulator of retrovirus infection.
• MRI-2 may be important in non-homologous end joining (NHEJ) of DNA double strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway.
• MRI-3