This section needs additional citations for verification. (August 2018) |
Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals. For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence, or combined drug intoxication which may lead to deaths.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/3/3a/Combo_2.png/290px-Combo_2.png)
Table
editTo avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.
Drug 1 | Drug 2 | Drug 3 | Drug 4 | Polysubstance slang,[2][3][4] or brand name |
Intoxication name | Comment |
---|---|---|---|---|---|---|
Any dissociative | Any dissociative | Void flip | Void flipping | |||
Any dissociative | DMT | Dime bar, angel flip | Dimension flipping, angel flipping | |||
Any depressant | Any stimulant | Speedball, powerball, over and under | Powerballing, speedballing[5] | |||
Any pharmaceutical | Any pharmaceutical | Polypharmacy | Pharming [citation needed] | Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.[6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.[6] | ||
Any drug | Cannabis | Amp joint[7] | ||||
Any drug | Nicotine | Cooler[5] | ||||
Any β-Carboline containing plant (e.g. Banisteriopsis caapi or Peganum harmala) |
DMT | Ayahuasca, Changa | Ayahuasca is drunk. Changa is smoked or vaped. | |||
Any antiretroviral drug | Black tar heroin | Whoonga, Nyaope [8] | Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone | |||
Any deliriant or diphenhydramine | MDMA | Nightmare flip | Nightmare flipping | |||
2C-B or the closely related 2C-x | LSD or any of the Lysergamides | MDMA or any Empathogen-entactogen | Ali flip[9][10] | Ali flipping[9][10] | This combination start as a classic Candyflip and end in a Nexus flip.
The LSD is taken first, followed by the MDMA 4 hours later and then 2C-B is taken 2 hours after the MDMA ( so 6 hours after the LSD ). MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY. This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping" with a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other. | |
2C-B | MDMA | Nexus flip[9][10] | Nexus flipping[9][10] | The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½).[11]
The 2C-B is supposed to help the empathogenic effect of the MDMA last longer. | ||
2C-B | DXM | Nexuswalk[12] | Nexuswalk | Nexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping | ||
2C-B | LSD | Gnome flip | ||||
2C-E | LSD | MDMA | Haychmaich flip[5] | Haychmaich flipping | ||
2C-P | 2C-E | Meskini Trip | Meskini Tripping | |||
2C-E | MDMA or any Empathogen-entactogen | 2C-B or the closely related 2C-x | Elias flip[5] | Elias flipping | The Elias Flipping inspired by the Ali Flip with the use of 2C-E instead of LSD. | |
2C-E | LSD or closely related Lysergamides | MDMA or any Empathogen | 2C-B or closely related 2C-x | Alias Flip | Alias flipping | The Alias flip is a very powerful mix between an Elias flip and an Ali flip. The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E. |
Alcohol | Benzodiazepine | Time flip | Time flipping | |||
Alcohol | Caffeine | Caffeinated alcoholic drink | ||||
Alcohol | Cannabis | Tincture of cannabis. Herb and Al. Judgement Day | Cross fading, twisting, getting twisted[13] | Called Judgement Day in Ghana when cannabis is added to the drink | ||
Alcohol | Cocaine | Snow-cone | Snow-coning | Ethanol is metabolized into cocaethylene[14] | ||
Alcohol | MDMA | Tipsy flip | Tipsy flipping | It may be dangerous | ||
Alcohol | Nicotine | Nicotini | A nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used. | |||
Amphetamine | Barbiturates | Inbetweens[15] | ||||
Amphetamine | Cannabis | LSD | Hippie heart attack [citation needed] | |||
Amphetamine | Cocaine | Snow seals | ||||
Amphetamine | Heroin | Bombido[15] | ||||
Amphetamine | Xanax | Orange Dream Blossom | Cloud Rush | The combination is crushed together and insufflated | ||
Belladonna | Hashish | Alamout black hash[5] | Mixed | |||
Caffeine | Cannabis | Hippie-speedball[16][17] | Hippie-speedballing | |||
Caffeine | Diphenhydramine | Sleep walk | Sleepwalking | |||
Caffeine | Methamphetamine | Ya ba, biker's coffee, kamikaze | ||||
Cacao bean | Magic mushroom | Aztec use of entheogens. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans. | ||||
CBD | THC | Low to moderate doses of CBD might reduce some of the paranoia, anxiety,[18] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.[19][20][21] Low doses of Kanna might also help counteract the anxiety.[22][23] | ||||
Cannabis | Cocoa solids | Cannabis-infused brownie | Cannabis edible | |||
Cannabis | Crack cocaine | Crack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola)[24] | Cocoa puffs, splitting | |||
Cannabis | Crack cocaine | Heroin | Major Pronin, El Diablo | |||
Cannabis | Crack cocaine | PCP | Jim Jones | |||
Cannabis | Damiana | Damiana and other herbs can be used as a tobacco alternative for rolling joints.[25] | ||||
Cannabis | DXM | Nicotine | Candy blunt | |||
Cannabis | Heroin or opium | A-bomb, Atom bomb, stuff[5] | ||||
Cannabis | MDMA | Stoner flip | Stoner flipping | |||
Cannabis | Ketamine | Stoner Kitty | ||||
Cannabis | Ketamine | Cocaine | Simmered | Getting Simmered | ||
Cannabis | Nicotine | Blunt, joint, spliff, Jonko | A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars. | |||
Cannabis | Opium | Demetra | ||||
Cannabis | PCP | Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom) | Illing | Wet is cannabis dipped in PCP [26] | ||
Cannabis | PCP | Nicotine | Wet blunt, dust blunt, dusted blunt, Kendrick Lamar blunt | Illing | ||
Cocaine | Heroin | Snowball. Other names: Belushi, bombita, murder one, whiz bang | Snowballing | |||
Cocaine | Heroin | LSD | Frisco special[5] | |||
Cocaine | Heroin | Nicotine | Flamethrower, primos | Cigarette laced with cocaine and heroin | ||
Cocaine | Ketamine | CK1, Calvin Klein, Cable, Party bag, Coquette | While CK1, Calvin Klein and Cable are all names for using both substances; a Party bag is in specific reference to when the substances are mixed in a single bag prior to use. | |||
Cocaine | Ketamine | MDMA | Ketamollicaine | |||
Cocaine | LSD | MDMA | Candy-flip on a string | Candy-flipping on a string | High risk on health | |
Cocaine | MDMA | Sugar flip | Sugar flipping | |||
Cocaine | Morphine | C & M | ||||
Cocaine | PCP | Space, whack | ||||
Cocaine | Wine | Coca wine | Ethanol is metabolized into cocaethylene | |||
Cocaine | Quetiapine | Q-ball | ||||
Codeine | Glutethimide | Pancakes and syrups | Combination of glutethimide and codeine cough syrup | |||
Codeine | Promethazine | Lean, purple drank, oil | ||||
Crack cocaine | Fentanyl | Dirty fentanyl, takeover [citation needed] | ||||
Crack cocaine | Heroin | Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar | ||||
Crack cocaine | LSD | Cracid, outerlimits | Cracid is a portmanteau of crack cocaine and acid [citation needed] | |||
Crack cocaine | Methamphetamine | Fire, twisters | ||||
Crack cocaine | Nicotine | Coolie, crimmie, woolas | A cigarette laced with crack [citation needed] | |||
Crack cocaine | Nicotine | PCP | Ozone | PCP and crack cigarette [citation needed] | ||
Crack cocaine | PCP | Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magic | Missile basing, space basing | |||
Diphenhydramine | DXM | OTC flip, counterflipping | OTC flipping, robowalking on a string | |||
DMT | LSD | Cosmo flip, Meadow flip | Cosmo flipping, meadow flipping | |||
DMT | LSD | Psilocybin or psilocybin mushroom | Super flip | Super flipping | Take LSD and shrooms then at the come up smoke DMT | |
DMT | MAOIs | Pharmahuasca | ||||
DMT | Psilocybin or psilocybin mushroom | Terence flip | Terence flipping | |||
DMT | Alcohol | Spyder, Spyder spin | Spyder spinning | |||
DXM | LSD | LSDXM | ||||
DXM | MDMA | Robo flip | Robo flipping | |||
DXM | Psilocybin or psilocybin mushroom | Cherry-bomb | Cherry-bombing | |||
Fentanyl | Heroin | Birria, chiva loca, Facebook | Facebook is mixed in a pill form [citation needed] | |||
Fentanyl (and/or heroin) |
Xylazine | Tranq, Tranq dope | "Tranq" is sometimes used to refer to xylazine by itself, but as a drug of abuse it is invariably combined with heroin or fentanyl | |||
GHB | MDMA | Gamma flip | Gamma flipping | |||
GHB | Methamphetamine | Cherry meth | ||||
Hashish | Crack cocaine | Double zero | ||||
Hashish | LSD | Royal temple ball | The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked. | |||
Hashish | Opium | Black hash, black Russian | ||||
Heroin | Methamphetamine | Goofball | ||||
Heroin | Morphine | New Jack swing | ||||
Heroin | PCP | Alien sex fiend[5] | ||||
Ketamine | LSD | Dolphin flip | Dolphin flipping | |||
Ketamine | MDMA | Kitty flip,[27] MK-ultra | Kitty flipping | |||
Ketamine | Psilocybin or Psilocybin mushrooms | Funky flip, chonk | Funky flipping, chonking | Fungus and K: one confirmed option is to ingest a low (0.75g) dose of psilocybin, wait 45 minutes, snort half a moderate dose of powdered ketamine, wait 10 minutes, snort the other half | ||
LSD | Caffeine | Hoffmann[28] Flip | Hoffmann flipping | Dose the LSD (amount of your choice). After 30 minutes drink 250ml of coffee and keep your usual coffee drinking habit throughout the day. | ||
LSD | Ketamine | MDMA | Holy Trident, Martin Luther King flip, Galaxy flip | Holy Tridenting, Martin Luther King flipping, Galaxy Flipping | ||
LSD | MDMA | Candy flip[9][10] | Candy flipping[29][9][10] | Generally, the MDMA is taken approximately 4 hours after the LSD ingestion. | ||
LSD | MDMA | Psilocybin or psilocybin mushroom | Jedi flip,[27] twilight flip | Jedi flipping, twilight flipping | ||
LSD | MDMA | Mushrooms | Ketamine | Quantum Flip | Quantum Flipping | Similar to Jedi flipping, but with a heavy dissociative effect induced by ketamine. The substances are taken in the order of LSD, Mushrooms, MDMA, then ketamine. Each substance should be taken at the peak of the previous substance to maximize the synergistic effects. Ketamine can be re-dosed as needed to extend the trip. The result is a highly visual and euphoric experience with periods of deep dissociation. |
LSD | Mescaline | Stella trip | ||||
LSD | Nitrous oxide | Gasid | ||||
LSD | PCP | Black acid | ||||
LSD | MDMA | Ketamine | Swalap Flip | Swalaped | ||
LSD | Psilocybin or psilocybin mushroom | God's flesh, Soul Bomb, Alice,[5] Wizard flip | Wizard flipping | |||
LSD | Any dissociative, particularly longer lasting ones such as MXE | (Optional) MDMA | Pixel flip | Pixel flipping | ||
LSD | Any dissociative, particularly longer lasting ones such as MXE | (Optional) MDMA | DMT | Pixie flip, portal flip | Pixie flipping, portal flipping | DMT is taken last. |
MDMA | Mescaline or psychoactive cactus | Love flip, love trip | Love flipping | |||
MDMA | Methadone | Chocolate flip | Chocolate flipping | |||
MDMA | Methamphetamine | Trailer flip | Trailer flipping | |||
MDMA | DMT | Shaman flip, time flip | Shaman flipping, time flipping | |||
MDMA | Nitrous oxide | Nox | ||||
MDMA | Opiates | Poppy flip | Poppy flipping | |||
MDMA | PCP | Domex, elephant flip | Elephant flipping | |||
MDMA | Psilocybin or psilocybin mushroom | Hippie flip | Hippie flipping[29] | |||
MDMA or any Empathogen-entactogen | 5-MeO-MiPT | 2C-B or the closely related 2C-x | Selma Flipping | Selma Flip | Keep the doses low, as 5-MeO-MiPT and Empathogen-entactogen can cause a Serotonin Syndrome at high doses, it's a Nexus Flip enhanced by 5-MeO-MiPT for psychedelic, entactogenic & erotic effects. | |
MDMA | Viagra (or other PDE5 inhibitors such as Cialis or Levitra) | Sextacy | ||||
MDMA | Xanax | Zen flip | Zen flipping | |||
MDMA | Ketamine | Mushrooms | Obama Flip | Obama Flipping | ||
Methamphetamine | Secobarbital, or other barbiturates | Poor man's speedball | ||||
Methamphetamine | Alpha-PVP | Cartel meth | So-called "cartel meth" is primarily composed of cutting agents such as isopropylbenzylamine and/or dimethylsulfone with a small proportion of methamphetamine plus the potent stimulant Alpha-PVP | |||
Methaqualone | Cannabis | White pipe[30][31] | Ingested by smoking. Popular in South Africa, elsewhere in Africa, and in India.[31] | |||
Nicotine | PCP | Chipping, fry cigarette | ||||
Pentazocine | Tripelannamine | T's and blues | ||||
Venlafaxine | Mirtazepine | California rocket fuel | None of the drugs are illegal and the combination is used for medical purposes. |
See also
editReferences
edit- ^ "Drug Combinations". combo.tripsit.me.
- ^ "Erowid Drug Slang & Terminology Vault : A - B". erowid.org.
- ^ Copping, Jasper (8 November 2009). "Drug slang: what police must learn A to B".
- ^ "Slang Terms and Code Words: A Reference for Law Enforcement Personnel". GovInfo. Retrieved 2024-07-06.
- ^ a b c d e f g h i "Erowid Drug Slang & Terminology Vault : A - B". erowid.org.
- ^ a b Masnoon, Nashwa; Shakib, Sepehr; Kalisch-Ellett, Lisa; Caughey, Gillian E. (October 2017). "What is polypharmacy? A systematic review of definitions". BMC Geriatrics. 17 (1): 230. doi:10.1186/s12877-017-0621-2. ISSN 1471-2318. PMC 5635569. PMID 29017448.
- ^ "Slang Terms for Drug Combinations". Narconon International. Retrieved 2021-12-08.
- ^ Grelotti DJ, Closson EF, Smit JA, Mabude Z, Matthews LT, Safren SA, Bangsberg DR, Mimiaga MJ. Whoonga: potential recreational use of HIV antiretroviral medication in South Africa. AIDS Behav. 2014 Mar;18(3):511-8. doi:10.1007/s10461-013-0575-0 PMID 23955659
- ^ a b c d e f "Ali Flip : Candy Flip & Nexus Flip melted". Chemical Collective. Retrieved 2024-03-29.
- ^ a b c d e f El Guennouni, Ali. "'Ali flip' LSD , MDMA & 2C-B use and combination in Therapy". chemical-collective.com. Retrieved 1 May 2023.
- ^ Weiss, Suzannah (2024-02-16). "Nexus Flipping: What Happens When You Combine MDMA and 2C-B". DoubleBlind Mag. Retrieved 2024-07-10.
- ^ "DXM & 2C-B - Erowid Exp - 'Nexuswalk - A Beautiful Mix of DXM and 2C-B'". erowid.org. Retrieved 2023-04-18.
- ^ Lankenau, Stephen; Clatts, Michael; Welle, Dorinda; Goldsamt, Lloyd; Gwadz, Marya (January 2005). "Street careers: homelessness, drug use, and sex work among young men who have sex with men (YMSM)". International Journal of Drug Policy. 16 (1): 10–18. doi:10.1016/j.drugpo.2004.07.006.
- ^ Pergolizzi, Joseph; Breve, Frank; Magnusson, Peter; LeQuang, Jo Ann K.; Varrassi, Giustino (2022-02-22). "Cocaethylene: When Cocaine and Alcohol Are Taken Together". Cureus. 14 (2): e22498. doi:10.7759/cureus.22498. ISSN 2168-8184. PMC 8956485. PMID 35345678.
- ^ a b Keup, Wolfram (June 1971). "The Vocabulary of the Drug User and Alcoholic: A Glossary". The International Journal of the Addictions. 6 (2): 348. doi:10.3109/10826087109057793. PMID 4950517. Retrieved 7 October 2021.
- ^ Crone, Madeline (2021-10-07). "Premiere: Singer-Songwriter Ben Chapman Defines a "Hippie Speedball" with a New Acoustic Video". American Songwriter. Retrieved 2024-07-27.
- ^ Rizzo, Melanie (2022-03-21). "Coffee Alternatives: A Modern Spin on the Hippie Speedball". TheBluntness. Retrieved 2024-07-27.
- ^ Gibson LP, Karoly HC, Ellingson JM, Klawitter J, Sempio C, Squeri JE, Bryan AD, Bidwell LC, Hutchison KE (2022). "Effects of cannabidiol in cannabis flower: Implications for harm reduction". Addiction Biology. 27 (1): e13092. doi:10.1111/adb.13092. PMC 9357513. PMID 34467598. S2CID 237372495.
- ^ Stuyt, Elizabeth (2018). "The Problem with the Current High Potency THC Marijuana from the Perspective of an Addiction Psychiatrist". Missouri Medicine. 115 (6): 482–486. ISSN 0026-6620. PMC 6312155. PMID 30643324.
- ^ ElSohly, Mahmoud A.; Mehmedic, Zlatko; Foster, Susan; Gon, Chandrani; Chandra, Suman; Church, James C. (2016-04-01). "Changes in Cannabis Potency over the Last Two Decades (1995-2014) - Analysis of Current Data in the United States". Biological Psychiatry. 79 (7): 613–619. doi:10.1016/j.biopsych.2016.01.004. ISSN 0006-3223. PMC 4987131. PMID 26903403.
- ^ Zamarripa, C. Austin; Spindle, Tory R.; Surujunarain, Renuka; Weerts, Elise M.; Bansal, Sumit; Unadkat, Jashvant D.; Paine, Mary F.; Vandrey, Ryan (2023-02-01). "Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial". JAMA Network Open. 6 (2): e2254752. doi:10.1001/jamanetworkopen.2022.54752. ISSN 2574-3805. PMC 9926328. PMID 36780161.
- ^ Sumpter, Luke (2022-12-29). "Combining Kanna with Weed or CBD: Should You Do It?". www.zamnesia.com. Retrieved 2023-02-05.
- ^ Manganyi, Madira Coutlyne; Bezuidenhout, Cornelius Carlos; Regnier, Thierry; Ateba, Collins Njie (2021-04-28). "A Chewable Cure "Kanna": Biological and Pharmaceutical Properties of Sceletium tortuosum". Molecules (Basel, Switzerland). 26 (9): 2557. doi:10.3390/molecules26092557. ISSN 1420-3049. PMC 8124331. PMID 33924742.
- ^ Tom Dalzell (2009), The Routledge Dictionary of Modern American Slang and Unconventional English, Routledge, ISBN 978-0-415-37182-7
- ^ Ewe, Koh (2021-04-19). "TikTokers Are Smoking Flowers As Weed Alternatives". www.vice.com. Retrieved 2021-12-24.
- ^ Holland, Julie A.; Nelson, Lewis; Ravikumar, P. R.; Elwood, William N. (22 February 2017). "Embalming Fluid-Soaked Marijuana: New High or New Guise for PCP?". Journal of Psychoactive Drugs. 30 (2): 215–219. doi:10.1080/02791072.1998.10399693. PMID 9692385. Retrieved 30 July 2021 – via Erowid.org.
- ^ a b Nolan, James (8 February 2019). "'Kitty flipping' and the Psychonaut Obsession with Mixing Drugs". VICE.com. Retrieved 16 July 2020.
- ^ "James Hoffmann". YouTube. Retrieved 2024-06-07.
- ^ a b Zeifman, Richard J.; Kettner, Hannes; Pagni, Broc A.; Mallard, Austin; Roberts, Daniel E.; Erritzoe, David; Ross, Stephen; Carhart-Harris, Robin L. (2023-08-22). "Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences". Scientific Reports. 13 (1): 13645. doi:10.1038/s41598-023-40856-5. ISSN 2045-2322. PMC 10444769.
- ^ "Mandrax". DrugAware. Reality Media. 2003. Retrieved 2009-08-13.
- ^ a b McCarthy G, Myers B, Siegfried N (April 2005). "Treatment for methaqualone dependence in adults". The Cochrane Database of Systematic Reviews (2): CD004146. doi:10.1002/14651858.CD004146.pub2. PMID 15846700.