Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.[5][6]

CA7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA7, CAVII, carbonic anhydrase 7, CA-VII
External IDsOMIM: 114770; MGI: 103100; HomoloGene: 55875; GeneCards: CA7; OMA:CA7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001014435
NM_005182
NM_001365337

NM_001301164
NM_001301165
NM_053070

RefSeq (protein)

NP_001014435
NP_005173
NP_001352266

NP_001288093
NP_001288094
NP_444300

Location (UCSC)Chr 16: 66.84 – 66.85 MbChr 8: 105.26 – 105.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168748Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031883Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16" (PDF). Genomics. 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. hdl:2027.42/29017. PMID 1783392.
  6. ^ a b "Entrez Gene: CA7 carbonic anhydrase VII".

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Carbonic anhydrase 7