Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.[5][6][7] It is a member of the alpha/beta fold hydrolase family.[8]

CES2
Identifiers
AliasesCES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2
External IDsOMIM: 605278; MGI: 3648740; HomoloGene: 128645; GeneCards: CES2; OMA:CES2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001272045

RefSeq (protein)

NP_001258974

Location (UCSC)Chr 16: 66.93 – 66.95 MbChr 8: 105.73 – 105.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]

Interactive pathway map

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Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|alt=Irinotecan Pathway edit]]
Irinotecan Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172831Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091813Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (June 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". The Journal of Biological Chemistry. 272 (23): 14769–14775. doi:10.1074/jbc.272.23.14769. PMID 9169443.
  6. ^ Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (April 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochemical and Biophysical Research Communications. 233 (1): 117–120. doi:10.1006/bbrc.1997.6413. PMID 9144407.
  7. ^ a b "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
  8. ^ Imai T (June 2006). "Human carboxylesterase isozymes: catalytic properties and rational drug design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

Further reading

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