This biographical article is written like a résumé. (June 2024) |
Carina Kern is a geneticist whose research focuses on the biology and genetics of ageing. She is CEO of LinkGevity Limited.[citation needed] Kern was previously a research fellow at the Department of Genetics, Evolution and Environment in the University College London. Her work concerns the underlying causes of aging, and how they give rise to the diseases of later life. She completed her PhD at the University College London's Division of Biosciences.
Kern is president of the London Evolutionary Network.[1] She is Co-Chair of the CleanTech Business Challenge,[2] an initiative co led by University College London and the London Business School.
Career
editKern has been an outspoken critic of what she argues are ideas that are inadequate to guide research towards an understanding of the aging process.[3] These include the concept of cellular senescence, which she argues has been outgrown by recent research progress.[4]
Her work on C. elegans challenged several decades of orthodoxy on notion of single gene switch-off mechanisms that could extend lifespan.[5][6] The work was cited in several main stream media outlets in the UK including Sky News,[7] Evening Standard[8] The Times[9] and The Independent[10]
Her work has also looked at how innate immune training can prevent infection at the level of whole organisms.[11]
Recent research
editKern's most recent work focuses on developing a novel theory of ageing focusing on the role of biological constraint as an explanation of how humans age.[12] She has also published work, that looks beyond the latest programmatic theories of ageing, and which seeks to explain the core molecular pathways at the heart of disease.[13]
References
edit- ^ "LERN Committee".
- ^ "CLEANTEH Committee".
- ^ "H-Span Podcast EP 8: Dr. Carina Kern". The Alliance For Longevity Initiatives Podcast.
- ^ Gems, D.; Kern, C. C. (2022). "Is 'cellular senescence' a misnomer?". GeroScience. 44 (5): 2461–2469. doi:10.1007/s11357-022-00652-x. PMC 9768054. PMID 36068483.
- ^ Kern, Carina C.; Townsend, Stjohn; Salzmann, Antoine; Rendell, Nigel B.; Taylor, Graham W.; Comisel, Ruxandra M.; Foukas, Lazaros C.; Bähler, Jürg; Gems, David (2021). "C. Elegans feed yolk to their young in a form of primitive lactation". Nature Communications. 12 (1): 5801. Bibcode:2021NatCo..12.5801K. doi:10.1038/s41467-021-25821-y. PMC 8492707. PMID 34611154.
- ^ Carina C. Kern; Shivangi Srivastava; Marina Ezcurra; Nancy Hui; StJohn Townsend; Dominik Maczik; Victoria Tse; Jürg Bähler; David Gems (November 16, 2020). "C. elegans hermaphrodites undergo semelparous reproductive death". bioRxiv 10.1101/2020.11.16.384255.
- ^ "The way worm mothers provide milk for their young 'could reveal key to slowing human ageing', researchers suggest".
- ^ "Worm mothers 'sacrifice themselves to provide milk for their young' – Researchers suggest the findings could help discover the key to slowing human ageing".
- ^ "Worm mothers 'sacrifice themselves to provide milk for their young'".
- ^ "Worm mothers 'sacrifice themselves' by providing milk for their young, scientists find".
- ^ Pérez-Hernández, C. Angélica; Kern, Carina C.; Butkeviciute, Egle; McCarthy, Elizabeth; Dockrell, Hazel M.; Moreno-Altamirano, María Maximina Bertha; Aguilar-López, Bruno A.; Bhosale, Gauri; Wang, Hongyuan; Gems, David; Duchen, Michael R.; Smith, Steven G.; Sánchez-García, Francisco Javier (2020). "Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. Elegans During Fumarate-Induced Innate Immune Training". Frontiers in Immunology. 11: 1715. doi:10.3389/fimmu.2020.01715. PMC 7419614. PMID 32849605.
- ^ Gems, David; Kern, Carina (2022). "Biological constraint as a cause of aging". Preprints. doi:10.20944/preprints202205.0212.v1.
- ^ Kern, Carina (2023). "Uncovering the Blueprint of Aging: How Aging Causes Late-Life Disease". Preprints. doi:10.20944/preprints202310.1387.v1.
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