Caroline Spencer is a character from the soap opera The Bold and the Beautiful.
Caroline Spencer may also refer to:
- Caroline Berryman Spencer (1861–1948), socialite and editor of Illustrated American
- Caroline Spencer, Duchess of Marlborough (1743–1811), wife of George Spencer, 4th Duke of Marlborough
- Caroline Spencer (suffragist) (1861–1928), American physician and suffragist