Cassuto is a surname. Notable people with the surname include:
- Judah Cassuto (1808–1893), Dutch-German hazzan (cantor) of the Portuguese-Jewish community
- Sherry Cassuto (1957-2016), American rower
- Solica Cassuto, Greek actress, and second wife of actor Andy Griffith
- Umberto Cassuto (1883–1951), Italian rabbi and Biblical scholar