Cebaracetam

Cebaracetam
Clinical data
Other names	CGS-25248; ZY-15119
ATC code	None;
Legal status
Legal status	US: Unscheduled and not FDA approved;
Identifiers
	IUPAC name 4-[2-[4-(4-Chlorophenyl)-2-oxopyrrolidin-1-yl]acetyl]piperazin-2-one;
CAS Number	113957-09-8 ;
PubChem CID	65919;
ChemSpider	59327 ;
UNII	Q25MNP6OC1;
ChEMBL	ChEMBL2105942 ;
CompTox Dashboard (EPA)	DTXSID70869580 ;
Chemical and physical data
Formula	C16H18ClN3O3
Molar mass	335.79 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CC(=O)N1)C(=O)CN2CC(CC2=O)C3=CC=C(C=C3)Cl;
	InChI InChI=1S/C16H18ClN3O3/c17-13-3-1-11(2-4-13)12-7-15(22)20(8-12)10-16(23)19-6-5-18-14(21)9-19/h1-4,12H,5-10H2,(H,18,21) ; Key:QPKMIYNBZGPJAR-UHFFFAOYSA-N ;
	(verify)

Cebaracetam (INNTooltip International Nonproprietary Name; developmental code names CGS-25248; ZY-15119) is an experimental drug of the racetam group described as a nootropic which was never marketed.^[1]^[2]^[3]

It is a chlorinated acetyl piperazine-substituted analogue of phenylpiracetam and is also a derivative of RGPU-95 (4-chlorophenylpiracetam).^[4] It is the analogue of RGPU-95 in which the terminal amide group has been replaced with a piperazin-2-one moiety.^[4] The mechanism of action of cebaracetam is undefined or unknown.^[1]

The drug was under development by Novartis for the treatment of cognition disorders by the 1990s but development was discontinued in 1995.^[1] It reached phase 2 clinical trials prior to its discontinuation.^[1]

References

^ ^a ^b ^c ^d "Cebaracetam". AdisInsight. 23 May 1995. Retrieved 1 October 2024.
^ https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf
^ Chollet D, Künstner P (June 1992). "Fast systematic approach for the determination of drugs in biological fluids by fully automated high-performance liquid chromatography with on-line solid-phase extraction and automated cartridge exchange. Application to cebaracetam in human urine". Journal of Chromatography. 577 (2): 335–340. doi:10.1016/0378-4347(92)80255-o. PMID 1400764.
^ ^a ^b "Cebaracetam". PubChem. Retrieved 1 October 2024.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

[AdisInsight-1] "Cebaracetam". AdisInsight. 23 May 1995. Retrieved 1 October 2024.

[WHO-INN-Stembook2018-2] ttps://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf

[CholletKünstner1992-3] Chollet D, Künstner P (June 1992). "Fast systematic approach for the determination of drugs in biological fluids by fully automated high-performance liquid chromatography with on-line solid-phase extraction and automated cartridge exchange. Application to cebaracetam in human urine". Journal of Chromatography. 577 (2): 335–340. doi:10.1016/0378-4347(92)80255-o. PMID 1400764.

[PubChem-4] "Cebaracetam". PubChem. Retrieved 1 October 2024.

[1]

[2]

[3]

[4]