Cenni is an Italian surname. Notable people with this surname include:
- Giovanni Cenni (1881–1957), Italian chess master
- Giuseppe Cenni (1915–1943), Italian aviator
- Maurizio Cenni (born 1955), Italian politician
- Quinto Cenni (1845–1917), Italian illustrator
- Roberto Cenni (born 1972), Italian politician
- Susanna Cenni (born 1963), Italian politician
- Valentina Cenni (born 1982), Italian artist and actress