Central Hotel may refer to:
- in Australia
- Central Hotel, Cairns, Queensland, Australia, a heritage-listed building
- Central Hotel, Stanthorpe, Queensland, Australia, a heritage-listed building
- in Ireland
- Central Hotel fire, Bundoran, Co Donegal, Ireland
- in the United Kingdom
- Central Hotel (Glasgow), Scotland
- Central Hotel, Douglas, Isle of Man, one of Isle of Man's Registered Buildings
- in the United States
- Central Hotel (Mount Joy, Pennsylvania), listed on the National Register of Historic Places