Cerebral dopamine neurotrophic factor

Cerebral dopamine neurotrophic factor also known as ARMET-like protein 1 is a protein that in humans is encoded by the CDNF gene.

CDNF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LPN, 2W50, 4BIT
Identifiers
Aliases	CDNF, ARMETL1, cerebral dopamine neurotrophic factor
External IDs	OMIM: 611233; MGI: 3606576; HomoloGene: 27965; GeneCards: CDNF; OMA:CDNF - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p13 Start 14,819,245 bp End 14,838,575 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A1 Start 3,514,067 bp End 3,527,413 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle left testis right testis sperm right uterine tube testicle Achilles tendon olfactory zone of nasal mucosa gonad Top expressed in quadriceps femoris muscle muscle of thigh skeletal muscle tissue esophagus spermatocyte zone of skin urinary bladder lip white adipose tissue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function growth factor activity Cellular component extracellular region extracellular space endoplasmic reticulum Biological process neuron projection development dopaminergic neuron differentiation regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 441549 227526 Ensembl ENSG00000185267 ENSMUSG00000039496 UniProt Q49AH0 Q8CC36 RefSeq (mRNA) NM_001029954 NM_177647 RefSeq (protein) NP_001025125 NP_808315 Location (UCSC) Chr 10: 14.82 – 14.84 Mb Chr 2: 3.51 – 3.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Choi JM, Hong JH, Chae MJ, Ngyuen PH, Kang HS, Ma HI, et al. (Apr 2011). "Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease". Neuroscience Letters. 493 (3): 97–101. doi:10.1016/j.neulet.2011.02.013. PMID 21320571. S2CID 207133072.
• Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, et al. (Dec 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, et al. (Apr 2009). "Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence". Neuroscience Letters. 453 (3): 199–203. doi:10.1016/j.neulet.2009.02.026. PMC 2680755. PMID 19429035.
• Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, et al. (Apr 2009). "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional". Protein Engineering, Design & Selection. 22 (4): 233–41. doi:10.1093/protein/gzn080. PMID 19258449.

External links

• Overview of all the structural information available in the PDB for UniProt: Q49AH0 (Cerebral dopamine neurotrophic factor) at the PDBe-KB.