Chakragati mouse (ckr) is an insertional transgenic mouse mutant (Mus musculus) displaying hyperactive behaviour and circling. It is also deficient in prepulse inhibition, latent inhibition[1] and has brain abnormalities such as lateral ventricular enlargement[2] that are typical to endophenotypic models of schizophrenia, which make it useful in screening for antipsychotic drug candidates.[3] The mouse is currently licensed by Chakra Biotech.
References
edit- ^ Verma V, Tan CH, Ong WY, et al. (March 2008). "The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition". Neurosci. Res. 60 (3): 281–8. doi:10.1016/j.neures.2007.11.007. PMID 18164085. S2CID 207150983.
- ^ Torres G, Meeder BA, Hallas BH, et al. (2005). "Ventricular size mapping in a transgenic model of schizophrenia". Developmental Brain Research. 154 (1): 35–44. doi:10.1016/j.devbrainres.2004.08.011. PMID 15617753.
- ^ Dawe GS, Ratty AK (2007). "The chakragati mouse: A mouse model for rapid in vivo screening of antipsychotic drug candidates". Biotechnology Journal. 2 (11): 1344–52. doi:10.1002/biot.200700145. PMID 17886239. S2CID 24748043.
External links
edit- Chakragati gene information on the ckr gene from Mouse Genome Informatics database
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