Chanoclavine-I dehydrogenase (EC 1.1.1.332, easD (gene), fgaDH (gene)) is an enzyme with systematic name chanoclavine-I:NAD+ oxidoreductase.[1][2] This enzyme catalises the following chemical reaction
| Chanoclavine-I dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.332 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- chanoclavine-I + NAD+ chanoclavine-I aldehyde + NADH + H+
This enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.
References
edit- ^ Wallwey C, Matuschek M, Li SM (February 2010). "Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH". Archives of Microbiology. 192 (2): 127–34. doi:10.1007/s00203-009-0536-1. PMID 20039019.
- ^ Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM (June 2012). "Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae". Microbiology. 158 (Pt 6): 1634–44. doi:10.1099/mic.0.056796-0. PMID 22403186.
External links
edit- Chanoclavine-I+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
