Charles Barker may refer to:
- Charles Barker (advertising agent) (1791–1859), English advertising agent
- Charles Barker (cricketer) (1847–1891), English cricketer
- Charles Barker (legislator), American politician
- Charles H. Barker (1935–1953), American Korean War soldier
- Charles S. Barker (1805–1879), British inventor and organ builder
- Charles Barker (politician) or Don Barker (1904–1956), Australian Labor Party politician