Charles Clay may refer to:
- Charles Clay (American football) (born 1989), American football fullback and tight end*
- Charles Clay (patriot) (1745–1820), minister, Virginia politician and planter, brother of Green Clay and Matthew Clay
- Charles Clay (surgeon) (1801–1893), English surgeon
- Sir Charles Travis Clay (1885–1978), English antiquary and librarian
- Chuck Clay (born 1950), American politician, state legislator from Georgia born Charles Commander Clay
This disambiguation page lists articles about people with the same name.
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