Charles Eastman (1858–1939) was a Santee Dakota physician, writer, national lecturer, and reformer.
Charles Eastman may also refer to:
- Charles K. Eastman (1929–2009), American screenwriter and script doctor
- Charles M. Eastman (1940–2020), American professor of architecture
- Charles R. Eastman (1868–1918), American geologist and palaeontologist
- Charles S. Eastman (1864–1939), American politician and lawyer