Charles Seymour (1885–1963) was an American academic, historian and President of Yale University.
Charles Seymour may also refer to:
- Charles Seymour, 2nd Baron Seymour of Trowbridge (1621–1665)
- Charles Seymour, 6th Duke of Somerset (1662–1748)
- Charles Seymour (cricketer) (1855–1934), English cricketer
- Charles Gurney Seymour, a fictional character in the political novel First Among Equals, by Jeffrey Archer
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