Chirino is a surname. Notable people with the surname include:
- José Leonardo Chirino (1754–1796), revolutionary
- Martín Chirino (1925–2019), Spanish sculptor
- Pedro Chirino (1557–1635), Spanish historian and Jesuit missionary
- Rogelio Chirino (born 1946), Cuban sprint canoeist
- Willy Chirino (born 1947), American singer
- Pedro Almíndez Chirino, Spanish conquistador