The Chlorobi-RRM RNA motif is a conserved RNA structure identified by bioinformatics.[1] It is found within bacteria in the phylum Chlorobiota (formerly Chlorobi), and is exclusively detected in the presumed 5' untranslated regions (5' UTRs) of genes that encode putative RNA-binding proteins. Since many RNA-binding proteins regulate their own expression in a feedback mechanism by binding or acting up their 5' UTR, it was proposed that the Chlorobi-RRM is a component in an analogous feedback mechanism. Structurally, the motif consists of two stem-loops, the second of which might function as a rho-independent transcription terminator.
| Chlorobi-RRM RNA | |
|---|---|
 Consensus secondary structure of Chlorobi-RRM RNAs | |
| Identifiers | |
| Symbol | Clorobi-RRM |
| Rfam | RF01697 |
| Other data | |
| RNA type | Cis-regulatory element |
| Domain(s) | Chlorobiota |
| PDB structures | PDBe |
References
edit- ^ Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol. 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC 2864571. PMID 20230605.
External links
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