Chromosome 19 open reading frame 33

Chromosome 19 open reading frame 33 is a protein that in humans is encoded by the C19orf33 gene.

C19orf33
Identifiers
Aliases	C19orf33, H2RSP, IMUP, IMUP-1, IMUP-2, chromosome 19 open reading frame 33
External IDs	MGI: 1919525; HomoloGene: 137645; GeneCards: C19orf33; OMA:C19orf33 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.2 Start 38,304,164 bp End 38,305,006 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B1 Start 28,945,986 bp End 28,947,891 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon olfactory zone of nasal mucosa skin of abdomen skin of leg duodenum right uterine tube upper lobe of left lung minor salivary glands rectum right lung Top expressed in duodenum left colon ileum yolk sac jejunum transitional epithelium of urinary bladder stomach epithelium of stomach migratory enteric neural crest cell left lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function double-stranded DNA binding single-stranded DNA binding Cellular component nucleus cytosol plasma membrane Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64073 72275 Ensembl ENSG00000167644 ENSMUSG00000030587 UniProt Q9GZP8 Q9D809 RefSeq (mRNA) NM_033520 NM_022125 NM_001317801 NM_028179 RefSeq (protein) NP_001304730 NP_277055 NP_082455 Location (UCSC) Chr 19: 38.3 – 38.31 Mb Chr 7: 28.95 – 28.95 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].

Further reading

• Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M (October 2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochem. Biophys. Res. Commun. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055.
• Kim JK, An HJ, Kim NK, Ahn JY, Kim KS, Kang YJ, Ko JJ, Oh D, Lee C, Kim SJ, Cha KY (2003). "IMUP-1 and IMUP-2 genes are up-regulated in human ovarian epithelial tumors". Anticancer Res. 23 (6C): 4709–13. PMID 14981917.
• Naganuma S, Itoh H, Uchiyama S, Nagaike K, Tanaka H, Akiyama Y, Chijiiwa K, Kataoka H (March 2006). "Nuclear translocation of H2RSP is impaired in regenerating intestinal epithelial cells of murine colitis model". Virchows Arch. 448 (3): 354–60. doi:10.1007/s00428-005-0064-6. PMID 16189703. S2CID 1817907.
• Betsunoh H, Mukai S, Akiyama Y, Fukushima T, Minamiguchi N, Hasui Y, Osada Y, Kataoka H (April 2007). "Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma". Cancer Sci. 98 (4): 491–8. doi:10.1111/j.1349-7006.2007.00412.x. PMC 11160002. PMID 17309599. S2CID 26220332.
• Kim SJ, An HJ, Kim HJ, Jungs HM, Lee S, Ko JJ, Kim IH, Sakuragi N, Kim JK (2008). "Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean and Japanese populations". Anticancer Res. 28 (2A): 865–71. PMID 18507030.
• Jeon SY, Lee HJ, Park JM, Jung HM, Yoo JK, Lee HJ, Lee JS, Cha DH, Kim JK, Kim GJ (May 2010). "Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia". J. Cell. Biochem. 110 (2): 522–30. doi:10.1002/jcb.22568. PMID 20432246. S2CID 42000298.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.