Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure,[1] occurring months to years after the transplant.
| Chronic allograft nephropathy | |
|---|---|
| Other names | Sclerosing/chronic allograft nephropathy |
 | |
| Micrograph of chronic allograft nephropathy. PAS stain. | |
| Specialty | Urology |
Symptoms and signs
editCAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.[2]
Pathology
editThe histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.[2][3]
Diagnosis
editCAN is diagnosed by examination of tissue, e.g. a kidney biopsy.[4]
References
edit- ^ Paul, LC. (Sep 1999). "Chronic allograft nephropathy: An update". Kidney Int. 56 (3): 783–93. doi:10.1046/j.1523-1755.1999.00611.x. PMID 10469349.
- ^ a b Joosten, SA.; Sijpkens, YW.; van Kooten, C.; Paul, LC. (Jul 2005). "Chronic renal allograft rejection: pathophysiologic considerations". Kidney Int. 68 (1): 1–13. doi:10.1111/j.1523-1755.2005.00376.x. PMID 15954891.
- ^ Nankivell, BJ.; Chapman, JR. (Mar 2006). "Chronic allograft nephropathy: current concepts and future directions". Transplantation. 81 (5): 643–54. doi:10.1097/01.tp.0000190423.82154.01. PMID 16534463. S2CID 30085431.
- ^ Fletcher, Jeffery T.; Nankivell, Brian J.; Alexander, Stephen I. (2009). "Chronic allograft nephropathy". Pediatric Nephrology. 24 (8). Springer Science and Business Media LLC: 1465–1471. doi:10.1007/s00467-008-0869-z. ISSN 0931-041X. PMC 2697362.