Chuckles may refer to:
- Chuck Bueche (AKA Chuckles), a game programmer
- Chuckles, a confectionery produced by Farley's & Sathers Candy Company, Inc.
- Chuckles (G.I. Joe), a fictional character from the G.I. Joe: A Real American Hero toyline
- Chuckles the Clown, a fictional character on The Mary Tyler Moore Show
- Chuckles, from Happy Tree Friends