The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons.[1] This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.[2]
| ciliary neurotrophic factor receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CNTFR | ||||||
| NCBI gene | 1271 | ||||||
| HGNC | 2170 | ||||||
| OMIM | 118946 | ||||||
| RefSeq | NM_001842 | ||||||
| UniProt | P26992 | ||||||
| Other data | |||||||
| Locus | Chr. 9 p13 | ||||||
| |||||||
References
edit- ^ Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD (1991). "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59–63. Bibcode:1991Sci...253...59D. doi:10.1126/science.1648265. PMID 1648265.
- ^ Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ (2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2–3): 265–72. doi:10.1016/S0031-6865(99)00050-3. PMID 10812968.
External links
edit- Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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