Class 78 may refer to:
- DRG Class 78, a German 4-6-4T tank locomotive class operated by the Deutsche Reichsbahn and Deutsche Bundesbahn comprising:
- Class 78.0-5: Prussian T 18, Württemberg T 18
- Class 78.6: BBÖ 729
- DB Class 78.10: DB rebuild from the DRG Class 38.10-40
This disambiguation page lists articles associated with the title Class 78.
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