Clijsters is a surname. Notable people with the surname include:
- Jos Clijsters (born 1950), Belgian banker and chief executive
- Lei Clijsters (1956-2009), Belgian football player
- Johan Clijsters (1962-2005), Belgian artist and poet
- Kim Clijsters (born 1983), Belgian tennis player and oldest daughter of Lei Clijsters
- Elke Clijsters (born 1985), Belgian tennis player and youngest daughter of Lei Clijsters