Clostridium scindens is a species of bacteria in the genus Clostridium that are found in the human gut.[1]
| Clostridium scindens | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Clostridiaceae |
| Genus: | Clostridium |
| Species: | C. scindens
|
| Binomial name | |
| Clostridium scindens Hall & O'Toole, 1935
| |
Like other members of the genus Clostridium, C. scindens is a Gram positive spore-forming anaerobe.[2]
Clostridium scindens is capable of converting primary bile acids to toxic secondary bile acids, as well as converting glucocorticoids to androgens by side-chain cleavage.[3]
Clostridium scindens may become established in the human colon, and its presence is associated with resistance to infection by Clostridioides difficile, due to production of secondary bile acids which inhibit the growth of C. difficile.[1][4]
References
edit- ^ a b Buffie, Charlie G.; Bucci, Vanni; Stein, Richard R.; McKenney, Peter T.; Ling, Lilan; Gobourne, Asia; No, Daniel; Liu, Hui; Kinnebrew, Melissa; Viale, Agnes; Littmann, Eric; Van Den Brink, Marcel R. M.; Jenq, Robert R.; Taur, Ying; Sander, Chris; Cross, Justin R.; Toussaint, Nora C.; Xavier, Joao B.; Pamer, Eric G. (2015). "Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile". Nature. 517 (7533): 205–208. Bibcode:2015Natur.517..205B. doi:10.1038/nature13828. PMC 4354891. PMID 25337874.
- ^ MORRIS, G. N.; WINTER, J.; CATO, E. P.; RITCHIE, A. E.; BOKKENHEUSER, V. D.YR 1985 (1985). "Clostridium scindens sp. nov., a Human Intestinal Bacterium with Desmolytic Activity on Corticoids". International Journal of Systematic and Evolutionary Microbiology. 35 (4): 478–481. doi:10.1099/00207713-35-4-478. ISSN 1466-5034.
{{cite journal}}: CS1 maint: numeric names: authors list (link) - ^ Ridlon, J. M.; Ikegawa, S.; Alves, J. M. P.; Zhou, B.; Kobayashi, A.; Iida, T.; Mitamura, K.; Tanabe, G.; Serrano, M.; De Guzman, A.; Cooper, P.; Buck, G. A.; Hylemon, P. B. (15 June 2013). "Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens". The Journal of Lipid Research. 54 (9): 2437–2449. doi:10.1194/jlr.M038869. PMC 3735941. PMID 23772041.
- ^ Studer, Nicolas; Desharnais, Lyne; Beutler, Markus; Brugiroux, Sandrine; Terrazos, Miguel A.; Menin, Laure; Schürch, Christian M.; McCoy, Kathy D.; Kuehne, Sarah A.; Minton, Nigel P.; Stecher, Bärbel; Bernier-Latmani, Rizlan; Hapfelmeier, Siegfried (2016). "Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model". Frontiers in Cellular and Infection Microbiology. 6: 191. doi:10.3389/fcimb.2016.00191. ISSN 2235-2988. PMC 5168579. PMID 28066726.
External links
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