Coagulation factor XIII B chain

Coagulation factor XIII B chain is a protein that in humans is encoded by the F13B gene.[5][6]

F13B
Identifiers
AliasesF13B, FXIIIB, coagulation factor XIII B chain
External IDsOMIM: 134580; MGI: 88379; HomoloGene: 1512; GeneCards: F13B; OMA:F13B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001994

NM_031164

RefSeq (protein)

NP_001985

NP_112441

Location (UCSC)Chr 1: 197.04 – 197.07 MbChr 1: 139.43 – 139.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.[7]

Interactions

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F13B has been shown to interact with Coagulation factor XIII A chain.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143278Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026368Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Grundmann U, Nerlich C, Rein T, Zettlmeissl G (Jun 1990). "Complete cDNA sequence encoding the B subunit of human factor XIII". Nucleic Acids Res. 18 (9): 2817–8. doi:10.1093/nar/18.9.2817. PMC 330776. PMID 2339067.
  6. ^ Bottenus RE, Ichinose A, Davie EW (Feb 1991). "Nucleotide sequence of the gene for the b subunit of human factor XIII". Biochemistry. 29 (51): 11195–209. doi:10.1021/bi00503a007. PMID 2271707.
  7. ^ "Entrez Gene: F13B coagulation factor XIII, B polypeptide".
  8. ^ Carrell, N A; Erickson H P; McDonagh J (Jan 1989). "Electron microscopy and hydrodynamic properties of factor XIII subunits". J. Biol. Chem. 264 (1). UNITED STATES: 551–6. doi:10.1016/S0021-9258(17)31294-2. ISSN 0021-9258. PMID 2491853.
  9. ^ Achyuthan, K E; Rowland T C; Birckbichler P J; Lee K N; Bishop P D; Achyuthan A M (Sep 1996). "Hierarchies in the binding of human factor XIII, factor XIIIa, and endothelial cell transglutaminase to human plasma fibrinogen, fibrin, and fibronectin". Mol. Cell. Biochem. 162 (1). NETHERLANDS: 43–9. doi:10.1007/bf00250994. ISSN 0300-8177. PMID 8905624. S2CID 23583301.

Further reading

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