Colón is a Spanish surname, comparable to the Italian and Portuguese Colombo, or English surname Columbus. Notable people with the surname include:
- Bartolo Colón (born 1973), Dominican baseball pitcher
- Carlos Colón, musician, member of The Deadlines
- Carlos Colón (born 1948), Puerto Rican wrestler
- Carly Colón (born 1979), Puerto Rican wrestler, son of Carlos Colón Sr.
- Christian Colón (born 1989), Puerto Rican baseball infielder
- Cristóbal Colón, the Spanish language name for the Italian explorer Christopher Columbus (1451–1506)
- Eddie Colón (born 1982), Puerto Rican wrestler, son of Carlos Colón Sr.
- Ernie Colón (1931–2019), American comics artist
- Jenniffer González-Colón (born 1976), Puerto Rican politician
- Jesús Colón (1901–1974), Puerto Rican writer and politician
- Kristiana Rae Colón (born 1986), American poet and playwright
- Orlando Colón (born 1982), Puerto Rican wrestler, nephew of Carlos Colón Sr.
- Willie Colón (born 1950), Puerto Rican American salsa musician