Colin Baigent (born 1961) is a British academic physician and cardiovascular epidemiologist. He is a professor of epidemiology, Director of the Medical Research Council Population Health Research Unit at the University of Oxford,[1] and deputy director of the Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), part of Oxford Population Health (the Nuffield Department of Population Health at the University of Oxford).[2] His work is focused in the design and coordination of large-scale randomised trials and the use of meta-analysis to assess the efficacy and safety of drugs for the prevention of cardiovascular disease (CVD) or premature death.[1]
Colin Baigent | |
|---|---|
| Nationality | British |
| Occupation(s) | Academic physician, and cardiovascular epidemiologist |
| Academic background | |
| Education | BA in Mathematics, BM BCh Medicine, MSc in Epidemiology |
| Alma mater | University of Oxford University of London |
| Academic work | |
| Institutions | University of Oxford |
Education
editBaigent was educated at St Bartholomew's School, Newbury, Berkshire. He studied mathematics at the University of Oxford, where he graduated in 1983. In 1995, he completed an MSc in epidemiology at the London School of Hygiene & Tropical Medicine, University of London.[3]
Career
editBaigent started his research career as a Junior Research Fellow at Green College at the University of Oxford in 1993. He was then appointed as an Honorary Senior Clinical Lecturer in 2000, Reader in Clinical Epidemiology in 2002, and since 2006 has served as a professor of epidemiology. He has been deputy director of the Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) since 2013 and Director of the MRC Population Health Research Unit at the University of Oxford since 2016. He is also an Honorary Consultant in cardiovascular epidemiology at the Oxford University Hospitals NHS Foundation Trust.[4]
Research
editChronic kidney disease and CVD
editBaigent pioneered the design and conduct of large-scale randomised trials in chronic kidney disease alongside Martin Landray. He served as Chief Investigator of the SHARP (Study of Heart and Renal Protection) trial, which recruited over 9,000 patients and established the efficacy and safety of lowering cholesterol in patients with chronic kidney disease.[5][6] More recently, his group has completed the EMPA-KIDNEY trial, which recruited over 6,600 patients, and demonstrated the efficacy and safety of empagliflozin for slowing progression of kidney disease.[7][8]
Cardiovascular epidemiology
editBaigent has coordinated many collaborative meta-analyses in which individual participant data from randomised controlled trials have been used to develop a better understanding of the effects and safety of drug treatments.[9] Since 1993, he has coordinated the Cholesterol Treatment Trialists’ (CTT) Collaboration with Rory Collins, which has provided information about the efficacy and safety of statin therapy in people with or without cardiovascular disease.[10][11] He has also coordinated the Antithrombotic Treatment Trialists’ (ATT) Collaboration, which has shown that daily low-dose aspirin does not result in a net benefit for primary prevention, whereas in secondary prevention the benefits of aspirin greatly outweigh the bleeding risks.[12][13]
Awards and honors
edit- 2005 – Elected Fellow, Faculty of Public Health, London
- 2006 – Elected Fellow, Royal College of Physicians, London
- 2015 – Elected Fellow, European Society of Cardiology[14]
- 2019 – Elected Fellow, Academy of Medical Sciences (United Kingdom)[15]
References
edit- ^ a b "Colin Baigent". www.mrc-phru.ox.ac.uk.
- ^ "Homepage — Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)". www.ctsu.ox.ac.uk.
- ^ "The story of cholesterol-lowering in kidney disease: from hypothesis to meta-analysis". The George Institute for Global Health.
- ^ "Our consultants - Oxford University Hospitals". www.ouh.nhs.uk.
- ^ Baigent, Colin; Landray, Martin J.; Reith, Christina; Emberson, Jonathan; Wheeler, David C.; Tomson, Charles; Wanner, Christoph; Krane, Vera; Cass, Alan; Craig, Jonathan; Neal, Bruce; Jiang, Lixin; Hooi, Lai Seong; Levin, Adeera; Agodoa, Lawrence; Gaziano, Mike; Kasiske, Bertram; Walker, Robert; Massy, Ziad A.; Feldt-Rasmussen, Bo; Krairittichai, Udom; Ophascharoensuk, Vuddidhej; Fellström, Bengt; Holdaas, Hallvard; Tesar, Vladimir; Wiecek, Andrzej; Grobbee, Diederick; Zeeuw, Dick de; Grönhagen-Riska, Carola; Dasgupta, Tanaji; Lewis, David; Herrington, William; Mafham, Marion; Majoni, William; Wallendszus, Karl; Grimm, Richard; Pedersen, Terje; Tobert, Jonathan; Armitage, Jane; Baxter, Alex; Bray, Christopher; Chen, Yiping; Chen, Zhengming; Hill, Michael; Knott, Carol; Parish, Sarah; Simpson, David; Sleight, Peter; Young, Alan; Collins, Rory (25 June 2011). "The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial". The Lancet. 377 (9784): 2181–2192. doi:10.1016/S0140-6736(11)60739-3. PMC 3145073. PMID 21663949.
- ^ "SHARP: Study of Heart and Renal Protection — Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)". www.ctsu.ox.ac.uk.
- ^ "EMPA-KIDNEY: the study of heart and kidney protection with empagliflozin — Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)". www.ctsu.ox.ac.uk.
- ^ The EMPA-KIDNEY Collaborative Group; et al. (12 January 2023). "Empagliflozin in Patients with Chronic Kidney Disease". The New England Journal of Medicine. 388 (2): 117–127. doi:10.1056/NEJMoa2204233. PMC 7614055. PMID 36331190.
- ^ "Vascular Meta-Analyses — Medical Research Council Population Health Research Unit (MRC PHRU)". www.mrc-phru.ox.ac.uk.
- ^ "CTT: Cholesterol Treatment Trialists' Collaboration — Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)". www.ctsu.ox.ac.uk.
- ^ "CTT Collaboration". www.cttcollaboration.org.
- ^ Antithrombotic Trialists' (ATT) Collaboration; Baigent, C.; Blackwell, L.; Collins, R.; Emberson, J.; Godwin, J.; Peto, R.; Buring, J.; Hennekens, C.; Kearney, P.; Meade, T.; Patrono, C.; Roncaglioni, M. C.; Zanchetti, A. (30 May 2009). "Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials". Lancet. 373 (9678): 1849–1860. doi:10.1016/S0140-6736(09)60503-1. PMC 2715005. PMID 19482214.
- ^ "ATT: Antithrombotic Trialists' Collaboration — Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)". www.ctsu.ox.ac.uk.
- ^ "Professor Colin Baigent". esc365.escardio.org.
- ^ "Professor Colin Baigent | The Academy of Medical Sciences". acmedsci.ac.uk.