College Street Historic District may refer to:
- College Street Historic District (Troy, Alabama), listed on the NRHP in Alabama
- College Street Historic District (Harrodsburg, Kentucky), listed on the NRHP in Kentucky
- College Street Historic District (Pikeville, Kentucky), listed on the NRHP in Kentucky
- College Street Historic District (Senatobia, Mississippi), listed on the NRHP in Mississippi
- College Street Historic District (Clinton, North Carolina), listed on the NRHP in North Carolina
- College Street Historic District (Newberry, South Carolina), listed on the NRHP in South Carolina