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Community Programs for Clinical Research on AIDS

The Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) was a program sponsored by National Institutes of Health (NIH) in the United States.[1][2] Started in 1989, CPCRA was instrumental in some research databases being established. Research from the programs assisted the evaluation of therapies for treating HIV in diverse populations.[citation needed]

History

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CPCRA was established in 1989[3] and included 15 research units. A Statistical Center at the University of Minnesota was funded from 1990 to 1997.[4][5]

CPCRA was one of four networks that NIH was using to conduct clinical trials that were looking to understand possible therapies for people with HIV infection.[6] Th CPCRA network was community-based with access to diverse populations across the spectrum of HIV diseases..."[7] The overall objective of the CPCRA is to design studies of sufficient size and duration of follow up to evaluate the long-term benefits and unintended consequences of various treatment strategies using available agents to assess long-term immunologic, virology and clinical outcomes. CPCRA trials are designed with nested sub-studies aimed at understanding the pathogenesis of HIV infection and the public health implications of its treatment.[8]

By 2001, CPCRA had 4,244 people participating in their studies, with trials underway in 17 cities.[9]

The International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) bio-repository system has its roots in the CPCRA.[10]

Research

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An antiretroviral medication self-reporting questionnaire was developed by the program.[11] The program organised the 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial: a large, long-term, randomised, prospective comparison of three different antiretroviral strategies in highly active antiretroviral therapy-naïve, HIV-1-infected persons.[12]

References

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  1. ^ Jacobson, M. A.; Besch, C. L.; Child, C.; Hafner, R.; Muth, K.; Deyton, L. (1991). "Clinical programs for clinical research on AIDS: Description of a randomized prospective study of clindamycin versus pyrimethamine for prevention of Toxoplasma gondii infection". European Journal of Clinical Microbiology & Infectious Diseases. 10 (3): 195–198. doi:10.1007/BF01964462. PMID 1676364. S2CID 8673486.
  2. ^ Cox, LE; Rouff, JR; Svendsen, KH; Markowitz, M; Abrams, DI (November 1998). "Community advisory boards: their role in AIDS clinical trials. Terry Beirn Community Programs for Clinical Research on AIDS" (PDF). Health Soc Work. 23 (4): 290–7. doi:10.1093/hsw/23.4.290. PMID 9834882. Archived from the original (PDF) on 2016-04-27. Retrieved 2016-04-21.
  3. ^ "An inventory of federally sponsored HIV and HIV-relevant databases. Database:Terry Beirn community programs for clinical research on AIDS (CPCRA) observational database (ODB)". Assistant Secretary for Planning and Evaluation (ASPE). 7 January 2000. Archived from the original on 27 April 2016. Retrieved 21 April 2016.
  4. ^ Neaton, James. "Community Programs for Clinical Research on AIDS" – via grantome.com. {{cite journal}}: Cite journal requires |journal= (help)
  5. ^ "RDAtlas". Archived from the original on 2016-05-09. Retrieved 2016-04-21.
  6. ^ "NIAID Research on AIDS" (Press release). aidsinfo.nih.gov. 1 January 1995. Retrieved 22 April 2016.
  7. ^ "CPCRA - Community Programs for Clinical Research on AIDS". Archived from the original on 2013-02-01. Retrieved 2012-08-08.
  8. ^ "Community Programs for Clinical Research on AIDS (CPCRA)". Archived from the original on July 3, 2007. Retrieved April 17, 2007.
  9. ^ "HIV Infections in Minority Populations" (Press release). aidsinfo.nih.gov. 1 June 2002. Retrieved 22 April 2016.
  10. ^ Huppler Hullsiek, Katherine; George, Michelle; Brown, Shawn K. (November 2010). "Designing and managing a flexible and dynamic biorepository system: a 15 year perspective from the CPCRA, ESPRIT, and INSIGHT clinical trial networks". Curr Opin HIV AIDS. 5 (6): 538–544. doi:10.1097/COH.0b013e32833f2058. PMC 3039520. PMID 20978398.
  11. ^ Mannheimer, Sharon; Friedland, Gerald; Matts, John; Child, Carroll; Chesney, Margaret (2002). "The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus—Infected Persons in Clinical Trials". Clinical Infectious Diseases. 34 (8): 1115–21. doi:10.1086/339074. PMID 11915001.
  12. ^ MacArthur, RD; Chen, L; Mayers, DL; Besch, CL; Novak, R; van den Berg-Wolf, M; Yurik, T; Peng, G; Schmetter, B; Brizz, B; Abrams, D (April 2001). "The rationale and design of the CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial". Control Clin Trials. 22 (2): 176–90. doi:10.1016/S0197-2456(01)00111-8. PMID 11306155.
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