Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cells.[1] It is a critical receptor for the phagocytosis of opsonised particles in the blood. It recognizes iC3b (inactivated C3b) deposited on microbial surfaces.
| V-set and immunoglobulin domain containing 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | VSIG4 | ||||||
| NCBI gene | 11326 | ||||||
| HGNC | 17032 | ||||||
| OMIM | 300353 | ||||||
| RefSeq | NM_007268 | ||||||
| UniProt | Q9Y279 | ||||||
| Other data | |||||||
| Locus | Chr. X q12-q13.3 | ||||||
| |||||||
See also
editReferences
edit- ^ Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, Scales S, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.
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