In neurophysiology, the Compound action potential (or CAP) refers to various evoked potentials representing the summation of synchronized individual action potentials generated by a group of neurons or muscle fibers in response to a stimulus.[1] Alike individual action potentials, CAP waveforms are typically biphasic presenting a negative and positive peak. The morphological attributes of the CAP (amplitude, spread, latency) depend on various factors including electrode placement, stimulus intensity, number of fibers recruited, the synchronization of action potentials, and conduction properties of the neural or muscular fibers.[2][3]
In most occurrences, the CAP refers to:
- the auditory compound action potential (CAP), generated by the auditory nerve,[4] or
- the compound muscle action potential (CMAP)[5]
References
edit- ^ "Compound action potential". APA Dictionary of Psychology. Washington, DC: American Psychological Association. n.d. Retrieved 12 March 2024.
- ^ Eggermont, Jos J. (2017-01-24). "Ups and Downs in 75 Years of Electrocochleography". Frontiers in Systems Neuroscience. 11: 2. doi:10.3389/fnsys.2017.00002. ISSN 1662-5137. PMC 5259695. PMID 28174524.
- ^ Kimura, Jun; Machida, Masafumi; Ishida, Tetsuro; Yamada, Thoru; Rodnitzky, Robert L.; Kudo, Yutaka; Suzuki, Shoji (1986). "Relation between size of compound sensory or muscle action potentials, and length of nerve segment". Neurology. 36 (5): 647–652. doi:10.1212/WNL.36.5.647. ISSN 0028-3878. PMID 3703263. S2CID 39488188.
- ^ Alamri, Yousef; Jennings, Skyler G. (1 April 2023). "Computational modeling of the human compound action potential". The Journal of the Acoustical Society of America. 153 (4): 2376. Bibcode:2023ASAJ..153.2376A. doi:10.1121/10.0017863. ISSN 1520-8524. PMC 10119875. PMID 37092943.
- ^ Barkhaus, Paul E.; Nandedkar, Sanjeev D.; de Carvalho, Mamede; Swash, Michael; Stålberg, Erik V. (2024). "Revisiting the compound muscle action potential (CMAP)". Clinical Neurophysiology Practice. 9: 176–200. doi:10.1016/j.cnp.2024.04.002. ISSN 2467-981X. PMC 11131082. PMID 38807704.