Wikipedia

Conjunctivitis

(Redirected from Conjunctivitus)
"Pinkeye" redirects here. For other uses, see Pinkeye (disambiguation).

Conjunctivitis, also known as pink eye or Madras eye,[4][5] is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid.[6] It makes the eye appear pink or reddish.[1] Pain, burning, scratchiness, or itchiness may occur.[1] The affected eye may have increased tears or be "stuck shut" in the morning.[1] Swelling of the white part of the eye may also occur.[1] Itching is more common in cases due to allergies.[3] Conjunctivitis can affect one or both eyes.[1]

Conjunctivitis
Other namesPink eye
An eye with viral conjunctivitis
SpecialtyOphthalmology, optometry
SymptomsReddish eye, scratchiness[1]
DurationViral conjunctivitis: up to two weeks[2]
CausesViral, bacterial, allergies[3]
Diagnostic methodBased on symptoms, microbial culture[1]
PreventionHandwashing[1]
TreatmentBased on underlying cause[3]
Frequency3–6 million per year (US)[1][3]

The most common infectious causes in adults are viral, whereas in children bacterial causes predominate.[7][3] The viral infection may occur along with other symptoms of a common cold.[1] Both viral and bacterial cases are easily spread between people.[1] Allergies to pollen or animal hair are also a common cause.[3] Diagnosis is often based on signs and symptoms.[1] Occasionally, a sample of the discharge is sent for culture.[1]

Prevention is partly by handwashing.[1] Treatment depends on the underlying cause.[1] In the majority of viral cases, there is no specific treatment.[3] Most cases due to a bacterial infection also resolve without treatment; however, antibiotics can shorten the illness.[1][3] People who wear contact lenses and those whose infection is caused by gonorrhea or chlamydia should be treated.[3] Allergic cases can be treated with antihistamines or mast cell inhibitor drops.[3]

About 3 to 6 million people get acute conjunctivitis each year in the United States.[1][3] Typically, people get better in one or two weeks.[1][3] If visual loss, significant pain, sensitivity to light or signs of herpes occur, or if symptoms do not improve after a week, further diagnosis and treatment may be required.[3] Conjunctivitis in a newborn, known as neonatal conjunctivitis, may also require specific treatment.[1]

Signs and symptoms

edit
 
Bloodshot eyes

Red eye, swelling of the conjunctiva, and watering of the eyes are symptoms common to all forms of conjunctivitis. However, the pupils should be normally reactive, and the visual acuity normal.[8]

Conjunctivitis is identified by inflammation of the conjunctiva, manifested by irritation and redness. Examination using a slit lamp (biomicroscope) may improve diagnostic accuracy. Examination of the palpebral conjunctiva, that overlying the inner aspects of the eyelids, is usually more diagnostic than examination of the bulbal conjunctiva, that overlying the sclera.[citation needed]

Viral

edit
 
Viral conjunctivitis

Approximately 80% of cases of conjunctivitis in adults and less than 20% in children are due to viruses, with 65% to 90% of these cases being attributed to adenoviruses.[3][7] Viral conjunctivitis is often associated with an infection of the upper respiratory tract, a common cold, or a sore throat. Other associated signs may include pre-auricular lymph node swelling and contact with another person with a red eye.[7] Eye pain may be present if the cornea is also involved.[7] Its symptoms include excessive watering and itching. The discharge in viral conjunctivitis is usually (but not always) watery in nature.[7] The infection usually begins in one eye but may spread easily to the other eye.[citation needed]

Viral conjunctivitis manifests as a fine, diffuse pinkness of the conjunctiva which may be mistaken for iritis, but corroborative signs on microscopy, particularly numerous lymphoid follicles on the tarsal conjunctiva, and sometimes a punctate keratitis are seen.[citation needed]

Allergic

edit
 
An eye with allergic conjunctivitis showing conjunctival edema

Allergic conjunctivitis is inflammation of the conjunctiva due to allergy.[9] The specific allergens may differ among patients. Symptoms result from the release of histamine and other active substances by mast cells, and consist of redness (mainly due to vasodilation of the peripheral small blood vessels), swelling of the conjunctiva, itching, and increased production of tears.[citation needed]

Bacterial

edit
 
An eye with bacterial conjunctivitis

Bacteria are responsible for approximately 70% of conjunctivitis in children and less than 20% of cases in adults.[7] Common bacteria responsible for bacterial conjunctivitis are Staphylococcus including Staph aureus, Streptococcus such as strep pneumoniae,[10] Haemophilus species and Moraxella catarrhalis.[7] Less commonly, Chlamydia spp. and Niesseria species (Neisseria gonorrhoeae and Neisseria meningitidis) may be the cause.[7][11] Infection with Escherichia coli may also cause conjunctivitis, particularly in the neonatal subtype ophthalmia neonatorum.[12] Bacterial conjunctivitis usually causes a rapid onset of conjunctival redness, swelling of the eyelid, and a sticky discharge. Typically, symptoms develop first in one eye, but may spread to the other eye within 2–5 days. Conjunctivitis due to common pus-producing bacteria causes marked grittiness or irritation and a stringy, opaque, greyish or yellowish discharge that may cause the lids to stick together, especially after sleep. Severe crusting of the infected eye and the surrounding skin may also occur. The gritty or scratchy feeling is sometimes localized enough that patients may insist that they have a foreign body in the eye.[citation needed]

 
Typical membranous conjunctivitis

Bacteria such as Chlamydia trachomatis or Moraxella spp. can cause a nonexudative but persistent conjunctivitis without much redness. Bacterial conjunctivitis may cause the production of membranes or pseudomembranes that cover the conjunctiva. Pseudomembranes consist of a combination of inflammatory cells and exudates and adhere loosely to the conjunctiva, while true membranes are more tightly adherent and cannot be easily peeled away. Cases of bacterial conjunctivitis that involve the production of membranes or pseudomembranes are associated with Neisseria gonorrhoeae, β-hemolytic streptococci, and Corynebacterium diphtheriae. C. diphtheriae causes membrane formation in conjunctiva of unimmunized children.[13]

Chemical

edit

Chemical eye injury may result when an acidic or alkaline substance gets in the eye.[14] Alkali burns are typically worse than acidic burns.[15] Mild burns produce conjunctivitis, while more severe burns may cause the cornea to turn white.[15] Litmus paper may be used to test for chemical causes.[14] When a chemical cause has been confirmed, the eye or eyes should be flushed until the pH is in the range 6–8.[15] Anaesthetic eye drops can be used to decrease the pain.[15]

Irritant or toxic conjunctivitis is primarily marked by redness. If due to a chemical splash, it is often present in only the lower conjunctival sac. With some chemicals, above all with caustic alkalis such as sodium hydroxide, necrosis of the conjunctiva marked by a deceptively white eye due to vascular closure may occur, followed by sloughing off of the dead epithelium. A slit lamp examination is likely to show evidence of anterior uveitis.[citation needed]

Biomarkers

edit

Omics technologies have been used to identify biomarkers that inform on the emergence and progression of conjunctivitis. For example, in chronic inflammatory cicatrizing conjunctivitis, active oxylipins, lysophospholipids, fatty acids, and endocannabinoids alterations, from which potential biomarkers linked to inflammatory processes were identified.[16]

Other

edit
 
An eye with chlamydial conjunctivitis

Inclusion conjunctivitis of the newborn is a conjunctivitis that may be caused by the bacterium Chlamydia trachomatis, and may lead to acute, purulent conjunctivitis.[17] However, it is usually self-healing.[17]

Causes

edit

Infective conjunctivitis is most commonly caused by a virus.[3] Bacterial infections, allergies, other irritants, and dryness are also common causes. Both bacterial and viral infections are contagious, passing from person to person or spread through contaminated objects or water. Contact with contaminated fingers is a common cause of conjunctivitis. Bacteria may also reach the conjunctiva from the edges of the eyelids and the surrounding skin, from the nasopharynx, from infected eye drops or contact lenses, from the genitals or the bloodstream.[18] Infection by human adenovirus accounts for 65% to 90% of cases of viral conjunctivitis.[19]

Viral

edit

Adenoviruses are the most common cause of viral conjunctivitis (adenoviral keratoconjunctivitis).[20] Herpetic keratoconjunctivitis, caused by herpes simplex viruses, can be serious and requires treatment with aciclovir. Acute hemorrhagic conjunctivitis is a highly contagious disease caused by one of two enteroviruses, enterovirus 70 and coxsackievirus A24. These were first identified in an outbreak in Ghana in 1969, and have spread worldwide since then, causing several epidemics.[21]

Bacterial

edit

The most common causes of acute bacterial conjunctivitis are Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.[20][22] Though very rare, hyperacute cases are usually caused by Neisseria gonorrhoeae or Neisseria meningitidis. Chronic cases of bacterial conjunctivitis are those lasting longer than 3 weeks, and are typically caused by S. aureus, Moraxella lacunata, or Gram-negative enteric flora.[citation needed]

Allergic

edit

Conjunctivitis may also be caused by allergens such as pollen, perfumes, cosmetics, smoke,[23][unreliable medical source?] dust mites, Balsam of Peru,[24] or eye drops.[25] The most frequent cause of conjunctivitis is allergic conjunctivitis and it affects 15% to 40% of the population.[26] Allergic conjunctivitis accounts for 15% of eye related primary care consultations; most including seasonal exposures in the spring and summer or perpetual conditions.[27]

Other

edit

Diagnosis

edit
 
The procedure of conjunctival swabs

Cultures are not often taken or needed as most cases resolve either with time or typical antibiotics. If bacterial conjunctivitis is suspected, but no response to topical antibiotics is seen, swabs for bacterial culture should be taken and tested. Viral culture may be appropriate in epidemic case clusters.[30]

A patch test is used to identify the causative allergen in allergic conjunctivitis.[31]

Although conjunctival scrapes for cytology can be useful in detecting chlamydial and fungal infections, allergies, and dysplasia, they are rarely done because of the cost and the general dearth of laboratory staff experienced in handling ocular specimens. Conjunctival incisional biopsy is occasionally done when granulomatous diseases (e.g., sarcoidosis)[32] or dysplasia are suspected.[33]

Classification

edit

Conjunctivitis may be classified either by cause or by extent of the inflamed area.[citation needed]

Causes

edit
  • Allergy
  • Bacteria
  • Viruses
  • Chemicals
  • Autoimmune

Neonatal conjunctivitis is often grouped separately from bacterial conjunctivitis because it is caused by different bacteria than the more common cases of bacterial conjunctivitis.[citation needed]

By extent of involvement

edit

Blepharoconjunctivitis is the dual combination of conjunctivitis with blepharitis (inflammation of the eyelids).[citation needed]

Keratoconjunctivitis is the combination of conjunctivitis and keratitis (corneal inflammation).[citation needed]

Blepharokeratoconjunctivitis is the combination of conjunctivitis with blepharitis and keratitis. It is clinically defined by changes of the lid margin, meibomian gland dysfunction, redness of the eye, conjunctival chemosis and inflammation of the cornea.[34]

Differential diagnosis

edit

Some more serious conditions can present with a red eye, such as infectious keratitis, angle-closure glaucoma, or iritis. These conditions require the urgent attention of an ophthalmologist. Signs of such conditions include decreased vision, significantly increased sensitivity to light, inability to keep the eye open, a pupil that does not respond to light, or a severe headache with nausea.[35] Fluctuating blurring is common, due to tearing and mucoid discharge. Mild photophobia is common. However, if any of these symptoms is prominent, considering other diseases such as glaucoma, uveitis, keratitis, and even meningitis or carotico-cavernous fistula is important.[citation needed]

A more comprehensive differential diagnosis for the red or painful eye includes:[35]

Prevention

edit

The most effective prevention is good hygiene, especially avoiding rubbing the eyes with infected hands. Vaccination against some of the causative pathogens such as Haemophilus influenzae, pneumococcus, and Neisseria meningitidis is also effective.[36]

Povidone-iodine eye solution has been found to prevent neonatal conjunctivitis.[37] It is becoming more commonly used globally because of its low cost.[37]

Management

edit

Conjunctivitis resolves in 65% of cases without treatment, within 2–5 days. The prescription of antibiotics is not necessary in most cases.[38]

Viral

edit

Viral conjunctivitis usually resolves on its own and does not require any specific treatment.[3] Antihistamines (e.g., diphenhydramine) or mast cell stabilizers (e.g., cromolyn) may be used to help with the symptoms.[3] Povidone-iodine has been suggested as a treatment, but as of 2008, evidence to support it was poor.[39]

Allergic

edit

For allergic conjunctivitis, cool water poured over the face with the head inclined downward constricts capillaries, and artificial tears sometimes relieve discomfort in mild cases. In more severe cases, nonsteroidal anti-inflammatory medications and antihistamines may be prescribed. Persistent allergic conjunctivitis may also require topical steroid drops.[40]

Bacterial

edit

Bacterial conjunctivitis usually resolves without treatment.[3] Topical antibiotics may be needed only if no improvement is observed after 3 days.[41] No serious effects were noted either with or without treatment.[42] Because antibiotics do speed healing in bacterial conjunctivitis, their use may be considered.[42] Antibiotics are also recommended for those who wear contact lenses, are immunocompromised, have disease which is thought to be due to chlamydia or gonorrhea, have a fair bit of pain, or have copious discharge.[3] Gonorrheal or chlamydial infections require both oral and topical antibiotics.[3]

The choice of antibiotic varies based on the strain or suspected strain of bacteria causing the infection. Fluoroquinolones, sodium sulfacetamide, or trimethoprim/polymyxin may be used, typically for 7–10 days.[20] Cases of meningococcal conjunctivitis can also be treated with systemic penicillin, as long as the strain is sensitive to penicillin.[citation needed]

When investigated as a treatment, povidone-iodine ophthalmic solution has also been observed to have some effectiveness against bacterial and chlamydial conjunctivitis, with a possible role suggested in locations where topical antibiotics are unavailable or costly.[43]

Chemical

edit

Conjunctivitis due to chemicals is treated via irrigation with Ringer's lactate or saline solution. Chemical injuries, particularly alkali burns, are medical emergencies, as they can lead to severe scarring and intraocular damage. People with chemically induced conjunctivitis should not touch their eyes to avoid spreading the chemical.[44]

Epidemiology

edit

Conjunctivitis is the most common eye disease.[45] Rates of disease is related to the underlying cause which varies by the age as well as the time of year. Acute conjunctivitis is most frequently found in infants, school-age children and the elderly.[18] The most common cause of infectious conjunctivitis is viral conjunctivitis.[26]

It is estimated that acute conjunctivitis affects 6 million people annually in the United States.[3]

Some seasonal trends have been observed for the occurrence of different forms of conjunctivitis. In the northern hemisphere, the occurrence of bacterial conjunctivitis peaks from December to April, viral conjunctivitis peaks in the summer months and allergic conjunctivitis is more prevalent throughout the spring and summer.[18]

History

edit

An adenovirus was first isolated by Rowe et al. in 1953. Two years later, Jawetz et al. published on epidemic keratoconjunctivitis.[46]: 437  "Madras eye" is a colloquial term that has been used in India for the disease.

Outbreak in Pakistan

edit
Main article: Pink eye outbreak in Pakistan

In September 2023, a significant outbreak of conjunctivitis occurred in Pakistan. The outbreak began in Karachi and quickly spread to Lahore, Rawalpindi, and Islamabad. By the end of the month, over 86,133 cases had been reported in Punjab alone. The rapid spread of the disease led to the temporary closure of schools in the region. This event marked one of the largest outbreaks of Pink Eye in the country's recent history.[47][48][49][50]

Society and culture

edit

Conjunctivitis imposes economic and social burdens. The cost of treating bacterial conjunctivitis in the United States was estimated to be $377 million to $857 million per year.[3] Approximately 1% of all primary care office visits in the United States are related to conjunctivitis. Approximately 70% of all people with acute conjunctivitis present to primary care and urgent care.[3]

See also

edit

References

edit
  1. ^ a b c d e f g h i j k l m n o p q r s "Facts About Pink Eye". National Eye Institute. November 2015. Archived from the original on 9 March 2016. Retrieved 8 March 2016.
  2. ^ Long SS, Prober CG, Fischer M (2017). Principles and Practice of Pediatric Infectious Diseases E-Book. Elsevier Health Sciences. p. 502. ISBN 978-0-323-46132-0.
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w Azari AA, Barney NP (October 2013). "Conjunctivitis: a systematic review of diagnosis and treatment". JAMA. 310 (16): 1721–1729. doi:10.1001/jama.2013.280318. PMC 4049531. PMID 24150468.
  4. ^ "What is Viral Conjunctivitis a.k.a. Sore Eyes? | National Institutes of Health".
  5. ^ Mohanasundaram AS, Gurnani B, Kaur K, Manikkam R (May 2023). "Madras eye outbreak in India: Why should we foster a better understanding of acute conjunctivitis?". Indian Journal of Ophthalmology. 71 (5): 2298–2299. doi:10.4103/IJO.IJO_3317_22. PMC 10391441. PMID 37202982.
  6. ^ Richards A, Guzman-Cottrill JA (May 2010). "Conjunctivitis". Pediatrics in Review. 31 (5): 196–208. doi:10.1542/pir.31-5-196. PMID 20435711. S2CID 245084568.
  7. ^ a b c d e f g h Durand ML, Barshak MB, Sobrin L (December 2023). "Eye Infections". The New England Journal of Medicine. 389 (25): 2363–2375. doi:10.1056/NEJMra2216081. PMID 38118024. S2CID 266433325.
  8. ^ Hashmi MF, Gurnani B, Benson S (2023). "Conjunctivitis". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 31082078. Retrieved 23 May 2023.
  9. ^ Bielory L, Friedlaender MH (February 2008). "Allergic conjunctivitis". Immunology and Allergy Clinics of North America. 28 (1): 43–58, vi. doi:10.1016/j.iac.2007.12.005. PMID 18282545. S2CID 34371872.
  10. ^ "Pink Eye (Conjunctivitis)". MedicineNet. Archived from the original on 22 June 2013.
  11. ^ "Acute Bacterial Conjunctivitis – Eye Disorders". Merck Manuals Professional Edition. Archived from the original on 28 December 2016. Retrieved 31 December 2016.
  12. ^ Saadeh-Jackson S, Rodriguez L, Leffler CT, Freymiller C, Wolf E, Wijesooriya N, et al. (August 2022). "Ophthalmia neonatorum due to Escherichia coli: A rare cause or an emerging bacterial etiology of neonatal conjunctivitis?". Clinical Case Reports. 10 (8): e6201. doi:10.1002/ccr3.6201. PMC 9354094. PMID 35949413.
  13. ^ Hamborsky J, Kroger A, Wolfe C, eds. (2015). Epidemiology and Prevention of Vaccine-Preventable Diseases. U.S. Dept. of Health & Human Services, Centers for Disease Control and Prevention. p. 112. ISBN 978-0-9904491-1-9.
  14. ^ a b Zentani A, Burslem J (December 2009). "Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 4: use of litmus paper in chemical eye injury". Emergency Medicine Journal. 26 (12): 887. doi:10.1136/emj.2009.086124. PMID 19934140. S2CID 38124735.
  15. ^ a b c d Hodge C, Lawless M (July 2008). "Ocular emergencies". Australian Family Physician. 37 (7): 506–509. PMID 18592066.
  16. ^ Di Zazzo A, Yang W, Coassin M, Micera A, Antonini M, Piccinni F, et al. (May 2020). "Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis". Journal of Molecular Medicine. 98 (5): 751–760. doi:10.1007/s00109-020-01907-w. PMC 7220886. PMID 32313985.
  17. ^ a b Fisher B, Harvey RP, Champe PC (2007). Lippincott's Illustrated Reviews: Microbiology (Lippincott's Illustrated Reviews Series). Hagerstown MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-8215-9.
  18. ^ a b c Høvding G (February 2008). "Acute bacterial conjunctivitis". Acta Ophthalmologica. 86 (1): 5–17. doi:10.1111/j.1600-0420.2007.01006.x. PMID 17970823. S2CID 20629824.
  19. ^ Singh MP, Ram J, Kumar A, Rungta T, Gupta A, Khurana J, et al. (2018). "Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India". Indian Journal of Medical Microbiology. 36 (1): 113–115. doi:10.4103/ijmm.ijmm_17_258. PMID 29735838.
  20. ^ a b c Yanoff M, Duker JS (2008). Ophthalmology (3rd ed.). Edinburgh: Mosby. pp. 227–236. ISBN 978-0-323-05751-6.
  21. ^ Lévêque N, Huguet P, Norder H, Chomel JJ (April 2010). "[Enteroviruses responsible for acute hemorrhagic conjunctivitis]". Médecine et Maladies Infectieuses (in French). 40 (4): 212–218. doi:10.1016/j.medmal.2009.09.006. PMID 19836177.
  22. ^ "Protect Yourself From Pink Eye". Centers for Disease Control and Prevention (CDC). 2 October 2017. Retrieved 7 December 2018.
  23. ^ "Allergic Conjunctivitis". familydoctor.org. Archived from the original on 6 September 2015. Retrieved 18 September 2015.
  24. ^ Brooks P (25 October 2012). The Daily Telegraph: Complete Guide to Allergies. Little, Brown Book. ISBN 978-1-4721-0394-9. Retrieved 15 April 2014.[permanent dead link]
  25. ^ "What Is Allergic Conjunctivitis? What Causes Allergic Conjunctivitis?". medicalnewstoday.com. Archived from the original on 16 March 2010. Retrieved 6 April 2010.
  26. ^ a b Mourad MS, Rihan RA (April 2018). "Prevalence of Different Eye Diseases excluding Refractive Errors Presented at the Outpatient Clinic in Beheira Eye Hospital". The Egyptian Journal of Hospital Medicine. 71 (2): 2484–2489. doi:10.12816/0045645. S2CID 80882721.
  27. ^ Perkin MR, Bader T, Rudnicka AR, Strachan DP, Owen CG (24 November 2015). "Inter-Relationship between Rhinitis and Conjunctivitis in Allergic Rhinoconjunctivitis and Associated Risk Factors in Rural UK Children". PLOS ONE. 10 (11): e0143651. Bibcode:2015PLoSO..1043651P. doi:10.1371/journal.pone.0143651. PMC 4658044. PMID 26600465.
  28. ^ Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". Joint Bone Spine. 81 (2): 118–124. doi:10.1016/j.jbspin.2014.01.001. PMID 24556284. S2CID 205754989.
  29. ^ Cantarini L, Vitale A, Brizi MG, Caso F, Frediani B, Punzi L, et al. (2014). "Diagnosis and classification of relapsing polychondritis". Journal of Autoimmunity. 48–49: 53–59. doi:10.1016/j.jaut.2014.01.026. PMID 24461536.
  30. ^ Sheikh A, Hurwitz B (2008). "BACTERIAL CONJUNCTIVITIS 372.05 (Infective Conjunctivitis, Mucopurulent Conjunctivitis, Purulent Conjunctivitis)". Roy and Fraunfelder's Current Ocular Therapy. Elsevier. pp. 332–334. doi:10.1016/b978-1-4160-2447-7.50182-1. ISBN 978-1-4160-2447-7.
  31. ^ Mannis MJ, Macsai MS, Huntley AC (1996). Eye and skin disease. Lippincott-Raven. ISBN 978-0-7817-0269-0. Archived from the original on 5 July 2014. Retrieved 23 April 2014.
  32. ^ Korkmaz Ekren P, Mogulkoc N, Toreyin ZN, Egrilmez S, Veral A, Akalın T, et al. (October 2016). "Conjunctival Biopsy as a First Choice to Confirm a Diagnosis of Sarcoidosis". Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 33 (3): 196–200. PMID 27758983.
  33. ^ Roberts F, Thum CK (2021). "The Conjunctival Biopsy". In Roberts F (ed.). Lee's Ophthalmic Histopathology. Cham: Springer International Publishing. pp. 343–388. doi:10.1007/978-3-030-76525-5_11. ISBN 978-3-030-76525-5.
  34. ^ O'Gallagher M, Banteka M, Bunce C, Larkin F, Tuft S, Dahlmann-Noor A (May 2016). "Systemic treatment for blepharokeratoconjunctivitis in children". The Cochrane Database of Systematic Reviews. 2016 (5): CD011750. doi:10.1002/14651858.CD011750.pub2. PMC 9257284. PMID 27236587.
  35. ^ a b Longo DL (2012). "Disorders of the Eye(Horton JC)". Harrison's Principles of Internal Medicine. McGra-Hill.
  36. ^ "Protect Yourself From Pink Eye". Centers for Disease Control and Prevention. 2 October 2017. Retrieved 18 October 2017.
  37. ^ a b Isenberg SJ (2003). "The ocular application of povidone-iodine". Community Eye Health. 16 (46): 30–31. PMC 1705857. PMID 17491857.
  38. ^ Rose P (August 2007). "Management strategies for acute infective conjunctivitis in primary care: a systematic review". Expert Opinion on Pharmacotherapy. 8 (12): 1903–1921. doi:10.1517/14656566.8.12.1903. PMID 17696792. S2CID 45899988.
  39. ^ Bartlett JD, Jaanus SD (2008). Clinical Ocular Pharmacology. Elsevier Health Sciences. pp. 454–. ISBN 978-0-7506-7576-5. Archived from the original on 3 December 2016.
  40. ^ Patel DS, Arunakirinathan M, Stuart A, Angunawela R (November 2017). "Allergic eye disease". BMJ. 359: j4706. doi:10.1136/bmj.j4706. PMID 29097360. S2CID 5316455.
  41. ^ Visscher KL, Hutnik CM, Thomas M (November 2009). "Evidence-based treatment of acute infective conjunctivitis: Breaking the cycle of antibiotic prescribing". Canadian Family Physician. 55 (11): 1071–1075. PMC 2776793. PMID 19910590.
  42. ^ a b Chen YY, Liu SH, Nurmatov U, van Schayck OC, Kuo IC (March 2023). "Antibiotics versus placebo for acute bacterial conjunctivitis". The Cochrane Database of Systematic Reviews. 3 (3): CD001211. doi:10.1002/14651858.CD001211.pub4. PMC 10014114. PMID 36912752.
  43. ^ Isenberg SJ, Apt L, Valenton M, Del Signore M, Cubillan L, Labrador MA, et al. (November 2002). "A controlled trial of povidone-iodine to treat infectious conjunctivitis in children". American Journal of Ophthalmology. 134 (5): 681–688. doi:10.1016/S0002-9394(02)01701-4. PMID 12429243.
  44. ^ "Conjunctivitis". American Optometric Association. Retrieved 15 March 2024.
  45. ^ Smeltzer SC (2010). Brunner & Suddarth's textbook of medical-surgical nursing (12th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 1787. ISBN 978-0-7817-8589-1. Archived from the original on 15 August 2016.
  46. ^ Jhanji V, Chan TC, Li EY, Agarwal K, Vajpayee RB (September–October 2015). "Adenoviral keratoconjunctivitis". Survey of Ophthalmology. 60 (5): 435–443. doi:10.1016/j.survophthal.2015.04.001. PMID 26077630.
  47. ^ "From pink eye to blindness". 28 September 2023.
  48. ^ "86,133 pink eye cases in Punjab in September and counting". 28 September 2023.
  49. ^ Ahmed S (27 September 2023). "Punjab Announces Holiday for Schools Amid Pink Eye Outbreak". Propakistani.
  50. ^ "85 new cases of Pink Eye infection reported in Pakistan's Lahore". ETHealthworld.com. Asian News International.
edit
 
Wikimedia Commons has media related to Conjunctivitis.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Conjunctivitis&oldid=1257092603"