Constantino is a Portuguese and Spanish given name. It is derived from Latin Constantinus. Constantino may refer to:
- Constantino Barza, Brazilian photgrapher
- Constantino Brumidi (1805–1880), born Costantino Brumidi, Italian-American painter
- Constantino Cajetan (1568–1650), also known as Costantino Gaetani, Italian scholar
- Constantino of Braganza (1528–1575), Portuguese nobleman
- Constantino Chiwenga (born 1956), real name Constantine Chiwenga, Zimbabwean politician
- Constantino Mollitsas (1899–1966), Brazilian association football player
- Florencio Constantino (1869–1919), Spanish operatic tenor
- Phil Constantino, a charachter in the Jericho television series
- Renato Constantino (1919–1999), Filipino historian