Copine 3

CPNE3
Identifiers
Aliases	CPNE3, CPN3, PRO1071, copine 3
External IDs	OMIM: 604207; MGI: 1917818; HomoloGene: 20839; GeneCards: CPNE3; OMA:CPNE3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	86,561,498 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	19,570,108 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; oral cavity; ; beta cell; ; bone marrow cells; ; Achilles tendon; ; myocardium of left ventricle; ; gums; ; mucosa of pharynx; ; gingival epithelium; ; skin of thigh;
	Top expressed in
	corneal stroma; ; lumbar spinal ganglion; ; conjunctival fornix; ; pyloric antrum; ; vestibular membrane of cochlear duct; ; pineal gland; ; granulocyte; ; epithelium of stomach; ; transitional epithelium of urinary bladder; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; receptor tyrosine kinase binding; protein serine/threonine kinase activity; calcium-dependent protein binding; transporter activity; calcium-dependent phospholipid binding; RNA binding;
Cellular component	extracellular exosome; cytoplasm; cytosol; cell junction; nucleus; membrane; focal adhesion; plasma membrane; nucleolus; mitochondrion; azurophil granule membrane;
Biological process	ERBB2 signaling pathway; glycerophospholipid biosynthetic process; lipid metabolism; cellular response to growth factor stimulus; positive regulation of cell migration; cellular response to calcium ion; vesicle-mediated transport; protein phosphorylation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	8895
	70568
	ENSG00000085719
	ENSMUSG00000028228
	O75131
	Q8BT60
	NM_003909
	NM_027769; NM_001356481
	NP_003900
	NP_082045; NP_001343410
	Wikidata
View/Edit Human	View/Edit Mouse

Copine 3 is a protein that in humans is encoded by the CPNE3 gene. ^[5]

Function

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000085719 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028228 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Copine 3". Retrieved 2018-01-16.

Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ (2008). "Multiple loci identified in a genome-wide association study of prostate cancer". Nat. Genet. 40 (3): 310–5. doi:10.1038/ng.91. PMID 18264096. S2CID 22978381.
Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ (2008). "Multiple loci identified in a genome-wide association study of prostate cancer". Nat. Genet. 40 (3): 310–5. doi:10.1038/ng.91. PMID 18264096. S2CID 22978381.
Heinrich C, Keller C, Boulay A, Vecchi M, Bianchi M, Sack R, Lienhard S, Duss S, Hofsteenge J, Hynes NE (2010). "Copine-III interacts with ErbB2 and promotes tumor cell migration". Oncogene. 29 (11): 1598–610. doi:10.1038/onc.2009.456. PMID 20010870.
Cohen OS, Mccoy SY, Middleton FA, Bialosuknia S, Zhang-James Y, Liu L, Tsuang MT, Faraone SV, Glatt SJ (2012). "Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia". Schizophr. Res. 142 (1–3): 188–99. doi:10.1016/j.schres.2012.09.015. PMC 3502694. PMID 23062752.
Lin HC, Zhang FL, Geng Q, Yu T, Cui YQ, Liu XH, Li J, Yan MX, Liu L, He XH, Li JJ, Yao M (2013). "Quantitative proteomic analysis identifies CPNE3 as a novel metastasis-promoting gene in NSCLC". J. Proteome Res. 12 (7): 3423–33. doi:10.1021/pr400273z. PMID 23713811.
Choi HY, Park N, Na JB, Ko ES, Park JY, Yoo JC (2016). "Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility in SKBr3 breast cancer cells". Oncol. Rep. 35 (2): 1147–52. doi:10.3892/or.2015.4472. PMID 26719032.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085719 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028228 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Copine 3". Retrieved 2018-01-16.

[5]

[1]

[2]

[3]

[4]

Copine 3

Function

References

Further reading