Coproporphyrinogen dehydrogenase

In enzymology, a coproporphyrinogen dehydrogenase (EC 1.3.99.22) is an enzyme that catalyzes the chemical reaction

coproporphyrinogen dehydrogenase
Identifiers
EC no.1.3.99.22
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
coproporphyrinogen III + 2 S-adenosyl-L-methionine protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Thus, the two substrates of this enzyme are coproporphyrinogen III and S-adenosyl-L-methionine, whereas its 4 products are protoporphyrinogen IX, CO2, L-methionine, and 5'-deoxyadenosine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating). Other names in common use include oxygen-independent coproporphyrinogen-III oxidase, HemF, HemN, radical SAM enzyme, and coproporphyrinogen III oxidase. This enzyme participates in porphyrin and chlorophyll metabolism. HemN is the Oxygen-independent oxidase produced in E. coli. HemF is the oxygen-dependent oxidase within E. coli. Importantly, only HemN utilizes S-adenosyl Methionine (SAM). Human variants of Coproporphyrinogen oxidase are cofactor-independent.[1][2][3]

References

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  1. ^ Fetzner, Susanne; Steiner, Roberto A. (2010-02-16). "Cofactor-independent oxidases and oxygenases". Applied Microbiology and Biotechnology. 86 (3): 791–804. doi:10.1007/s00253-010-2455-0. hdl:11577/3402980. ISSN 0175-7598. PMID 20157809.
  2. ^ Layer, Gunhild; Moser, Jürgen; Heinz, Dirk W.; Jahn, Dieter; Schubert, Wolf-Dieter (2003-12-01). "Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes". The EMBO Journal. 22 (23): 6214–6224. doi:10.1093/emboj/cdg598. ISSN 0261-4189. PMC 291839. PMID 14633981.
  3. ^ Breckau, Daniela; Mahlitz, Esther; Sauerwald, Anselm; Layer, Gunhild; Jahn, Dieter (2003-11-21). "Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese". The Journal of Biological Chemistry. 278 (47): 46625–46631. doi:10.1074/jbc.M308553200. ISSN 0021-9258. PMID 12975365.