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Cuomo (/ˈkwoʊmoʊ/ KWOH-moh, Italian: [ˈkwɔːmo]) is an Italian surname. Notable people with the surname include:
- Politically involved Cuomo family, in the United States
- Mario Cuomo (1932–2015), governor of New York (1983–1995)
- Matilda Cuomo (born 1931), first lady of New York (1983–1995)
- Margaret Cuomo (born 1955), American radiologist and author
- Andrew Cuomo (born 1957), governor of New York (2011–2021)
- Chris Cuomo (born 1970), American journalist
- Chris Cuomo (philosopher), American philosopher
- Donna Cuomo (born 1947), member of the Massachusetts House of Representatives (1993–1999)
- Douglas J. Cuomo (born 1958), American composer
- Franco Cuomo (1938–2007), Italian journalist
- George Michael Cuomo (1929–2015), American author
- Leandro Cuomo (born 1996), Argentine footballer
- Luigi Cuomo (1905–1993), Italian fencer
- Nancy Cuomo (born 1946), Italian singer
- Rivers Cuomo (born 1970), American musician and frontman of the band Weezer
- Yolanda Cuomo (born 1957), American artist